Marker for detecting early diabetic nephropathy and application method of marker

Abstract

The invention discloses a marker for detecting early diabetic nephropathy and an application methodof the marker. The application method includes the steps that a TTP is used as the diagnostic markerof diabetic nephropathy, TTP expression levels in blood and urine samples of a diabetic nephropathy patient are detected to be compared with normal values of a TTP expression level, and the illness state is diagnosed after difference analysis of the TTP expression level. According to the application method, early diabetic patients without clinical proteinuria but with actually developed diabetic kidney injury can be found, the diagnosis rate of early diabetic nephropathy is increased, and a basis for diagnosis of diabetic nephropathy is provided; and compared with traditional use of clinical symptoms, the advantage of early diagnosis is achieved, and compared with kidney puncture biopsy, the advantage of noninvasive diagnosis is achieved.

Description

technical field [0001] The invention relates to the technical field of clinical diagnosis, in particular to a marker for detecting early diabetic nephropathy and an application method. Background technique [0002] At present, the existing technologies commonly used in the industry are as follows: Diabetic nephropathy is one of the most common and serious complications of diabetes, and has become the main cause of end-stage renal disease, with proteinuria as the main clinical manifestation. Clinically, the diagnosis of diabetic nephropathy involving the kidneys in diabetic patients is mainly based on the detection of urine protein. This method can only detect patients with proteinuria, and cannot diagnose kidney damage caused by diabetes without clinical proteinuria. . [0003] The present invention utilizes TTP (Tristetraprolin, which is a prototype member of the CCCH-type zinc finger family of zinc finger protein (ZFP36) RNA-binding protein, and can regulate the expressi...

AI Technical Summary

Problems solved by technology

[0005] (1) There is no clear diagnostic standard for early diabetes; the diagnosis of diabetic nephropathy depends on clinical symptoms or renal biopsy, and there is still a lack of technology to use biomarkers in the early stage of the disease to achieve early diagnosis

[0006] (2) Early diabetes without clinical proteinuria cannot be found; the early diagnosis of diabetic nephropathy is often based on the level of microalbuminuria, which cannot fully reflect the degree of disease

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