Marker for detecting early diabetic nephropathy and application method of marker

A technology for early detection of diabetic nephropathy, applied in the field of clinical diagnosis, can solve the problems of early diabetes without clear diagnostic criteria, unable to detect early diabetes without clinical proteinuria, and unable to fully reflect the degree of disease, so as to improve the diagnosis rate and feasibility. high effect

Pending Publication Date: 2019-05-17
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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Problems solved by technology

[0005] (1) There is no clear diagnostic standard for early diabetes; the diagnosis of diabetic nephropathy depends on clinical symptoms or renal biopsy, and there is still a lack of technology to use biomarkers in the early stage of the disea

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  • Marker for detecting early diabetic nephropathy and application method of marker

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Embodiment Construction

[0017] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0018] The application principle of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0019] The diagnostic marker of early diabetic nephropathy provided by the embodiment of the present invention is TTP.

[0020] Such as figure 1 As shown, the application method of the markers for detecting early diabetic nephropathy provided by the embodiments of the present invention includes the following steps:

[0021] S101: Use the marker TTP as a diagnostic marker for diabetic nephropathy, and detect the expression level of TTP in blood and urine samples of patients with diab...

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Abstract

The invention discloses a marker for detecting early diabetic nephropathy and an application methodof the marker. The application method includes the steps that a TTP is used as the diagnostic markerof diabetic nephropathy, TTP expression levels in blood and urine samples of a diabetic nephropathy patient are detected to be compared with normal values of a TTP expression level, and the illness state is diagnosed after difference analysis of the TTP expression level. According to the application method, early diabetic patients without clinical proteinuria but with actually developed diabetic kidney injury can be found, the diagnosis rate of early diabetic nephropathy is increased, and a basis for diagnosis of diabetic nephropathy is provided; and compared with traditional use of clinical symptoms, the advantage of early diagnosis is achieved, and compared with kidney puncture biopsy, the advantage of noninvasive diagnosis is achieved.

Description

technical field [0001] The invention relates to the technical field of clinical diagnosis, in particular to a marker for detecting early diabetic nephropathy and an application method. Background technique [0002] At present, the existing technologies commonly used in the industry are as follows: Diabetic nephropathy is one of the most common and serious complications of diabetes, and has become the main cause of end-stage renal disease, with proteinuria as the main clinical manifestation. Clinically, the diagnosis of diabetic nephropathy involving the kidneys in diabetic patients is mainly based on the detection of urine protein. This method can only detect patients with proteinuria, and cannot diagnose kidney damage caused by diabetes without clinical proteinuria. . [0003] The present invention utilizes TTP (Tristetraprolin, which is a prototype member of the CCCH-type zinc finger family of zinc finger protein (ZFP36) RNA-binding protein, and can regulate the expressi...

Claims

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Application Information

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IPC IPC(8): G01N33/68
Inventor 刘风勋刘东伟刘章锁乔颖进郭佳潘少康段家宇逯明蕾
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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