Microcapsule for controllably releasing medicines in tumor cells to treat breast cancers

Abstract

The invention discloses a microcapsule for controllably releasing medicines in tumor cells to treat breast cancers. The microcapsule comprises a temperature-sensitive hydrogel, a medicine and a magnetic material, wherein the surface of the temperature-sensitive hydrogel is loaded with phosphatidylcholine. The microcapsule is characterized in that by applying a magnetic field near the tumor tissues, when the medicine flows to the area near the tumor tissues along with fluid, the microcapsule containing the magnetic material is retained near the cells of the tumor tissues under the function of the additional fixed magnetic field; according to the characteristic of cancer cells directly absorbing choline under the endocytosis function, the temperature-sensitive hydrogel microcapsule with surface loaded with the phosphatidylcholine is directly absorbed into the tumor cells; by applying an alternating current magnetic field, the magnetic material produces heat under the function of the additional alternating current magnetic field to heat the microcapsule; when the critical transition temperature of the temperature-sensitive hydrogel is reached, the hydrogel generates phase change within very short time, so as to release the medicine out of the microcapsule, greatly improve the action efficiency of the medicine, and reduce the toxic or side effect of the medicine.

Description

Technical field [0001] The invention relates to a drug delivery capsule, in particular to a microcapsule for active-passive coordinated delivery of drugs into tumor tissue cells and controlled release to treat breast cancer. Background technique [0002] Breast cancer is one of the most common malignant tumors in women, seriously affecting women's physical and mental health, and even life-threatening. The incidence of breast cancer in China ranks first among female cancers, and the mortality rate ranks sixth among female cancer deaths. At present, the main methods of breast cancer treatment include: surgical treatment, radiotherapy, chemotherapy and so on. Each of these methods has its own advantages and disadvantages, but they also complement each other. Among them, chemotherapy is effective in treating micrometastases that may exist after surgery or radiotherapy, preventing their recurrence, and relatively limited tumors. But at the same time, due to the low selectivity of c...

AI Technical Summary

Problems solved by technology

But at the same time, due to the low selectivity of chemotherapy drugs, it will inevitably damage the normal cells of the human body while killing cancer cells, resulting in adverse drug reactions.

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