Double-layer nanofiber membrane composite drug-carrying adhesive patch and preparation method thereof

Abstract

The invention discloses a double-layer nanofiber membrane composite drug-carrying adhesive patch and a preparation method thereof and belongs to the technical field of medical and biomedical materials. A burst release medicament layer, a slow release medicament layer and an adhesive film of the nanofiber membrane structure are compounded, the burst release medicament layer and the slow release medicament layer can load different types of medicaments, reasonable distribution is carried out according to wound conditions, gradient release is formed, and the optimal treatment effect is achieved. The nanofiber membrane serving as a carrier has the advantages of being high in specific surface area, high in porosity, moisture-permeable, breathable, fine in fiber diameter and the like, can increase the loading amount of drugs, is high in porosity and beneficial to growth and proliferation of cells, promotes rapid healing of a wound surface, can simulate the natural environment of mucosa or skin through moisture-permeable, is beneficial to growth of new cells of the wound surface, can provide more growth sites for the cells through fine fiber diameter and can accelerate wound surface repair.

Description

technical field [0001] The invention belongs to the technical field of medical and biomedical materials, in particular to a double-layer nanofiber membrane composite drug-loaded adhesive patch and a preparation method thereof. Background technique [0002] In recent years, drug-loaded adhesive patches have developed rapidly both at home and abroad, and the use of drug-loaded adhesive patches can effectively promote wound healing. However, the current conventional drug-loaded adhesive patch has a single drug effect, and the drug does not have a gradient release effect; and the existing drug carrier film has poor adhesion and is easy to fall off, and the drug loading is limited; the porosity is not high. High moisture permeability and poor air permeability are not conducive to the growth and reproduction of cells. [0003] Nanofiber material is a new type of ultrafine fiber raw material, which has attracted the attention of researchers for its advantages such as high specific...

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Problems solved by technology

[0004] In order to solve the above problems, the object of the present invention is to provide a double-layer nanofiber membrane composite drug-loaded adhesive patch and a preparation method thereof, which adopts a double-layer drug structure in which burst-release agents and sustained-release agents are loaded on the nanofiber membrane, It solves the problem that the single-layer drug-loaded adhesive patch has a single drug effect and the drug cannot form a gradient release; and the good performance of the nanofiber material can improve the effect of the drug-loaded adhesive patch

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