Anti-skid, self-dilating and degradable esophagus stent with negative Poisson's ratio structure and preparation of stent

A negative Poisson's ratio, anti-slip technology, applied in stents and other directions, can solve problems such as difficulty, easy displacement or slippage complications of esophageal stents, obvious later removal and other problems, achieve good radial support force, facilitate implantation in the esophagus, Reduce the effect of displacement and slippage

Active Publication Date: 2019-06-18
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide an esophageal stent with a negative Poisson’s ratio effect and a degradable function, which mainly solves the problem of easy displacement or slippage of the esophageal stent and the obvious complications caused by non-degradable materials and the difficulty in taking it out later And other issues

Method used

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  • Anti-skid, self-dilating and degradable esophagus stent with negative Poisson's ratio structure and preparation of stent
  • Anti-skid, self-dilating and degradable esophagus stent with negative Poisson's ratio structure and preparation of stent

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preparation example Construction

[0034] Preparation of PCL multifilament wrapping PPDO monofilament: 4 PCL multifilaments are uniformly coated on the surface of PPDO monofilament by weaving process to obtain PPDO CY . C12-spindle knitting machine is used, PPDO monofilament is used as the central axis yarn, four PCL multifilaments are evenly placed on the weaving track around the axis yarn, and all yarns are connected with the pulling load before weaving. in PPDO CY In the weaving preparation process of PCL, a larger weaving density is obtained by controlling the moderate reduction of the pulling speed, which makes the weaving and covering structure of PCL more compact. Observation of woven and formed PPDO CY , PCL multifilament forms an obvious weaving structure on the surface of PPDO monofilament, and the covering effect is tight. Using MB-Ruler to measure, the measured diameter of PPDO monofilament is 0.23±0.02mm, PPDO CY The diameter of the covered yarn is 0.32±0.01mm. (Wu Siwei, Design and preparatio...

Embodiment 1

[0039] Such as figure 1 As shown, the anti-slip self-expanding degradable esophageal tube stent with a negative Poisson’s ratio structure in this embodiment includes a tubular stent body, and the stent body includes an upper end 1, a middle portion 2, and a lower end 3 connected in sequence, and the upper end The top end of 1 and the bottom end of the lower end part 3 respectively form an upper port and a lower port, and the inner diameters (inner diameter) of the upper port and the lower port are larger than the inner diameter (inner diameter) of the middle part 2 . In order to realize the effect of radial support, the two ends are enlarged, the upper end and the lower end are bell-shaped, and the transition section is between the middle part 2 and the upper and lower ports.

[0040]The main body of the stent is constructed by weaving means of PCL multifilament wrapped with PPDO monofilament loaded with drug (active ingredient KY3 of Rubescens japonicus). The middle part of ...

Embodiment 2

[0048] Such as figure 1 As shown, the anti-slip self-expanding degradable esophageal tube stent with a negative Poisson’s ratio structure in this embodiment includes a tubular stent body, and the stent body includes an upper end 1, a middle portion 2, and a lower end 3 connected in sequence, and the upper end The top end of 1 and the bottom end of the lower end part 3 respectively form an upper port and a lower port, and the inner diameters (inner diameter) of the upper port and the lower port are larger than the inner diameter (inner diameter) of the middle part 2 . In order to realize the effect of radial support, the two ends are enlarged, the upper end and the lower end are bell-shaped, and the transition section is between the middle part 2 and the upper and lower ports.

[0049] The main body of the stent is constructed by weaving means of PCL multifilament wrapped with PPDO monofilament loaded with drug (active ingredient KY3 of Rubescens japonicus). The middle part of...

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Abstract

The invention provides an anti-skid, self-dilating and degradable esophagus stent with a negative Poisson's ratio structure. The anti-skid, self-dilating and degradable esophagus stent with the negative Poisson's ratio structure is characterized by comprising a main stent body made of a totally or partially degradable material, wherein the main stent body comprises an upper end part, a middle partand a lower end part which are connected in sequence, an upper port and a lower port are formed in the top end of the upper end part and the bottom end of the lower end part respectively, and inner diameter of the upper port and inner diameter of the lower port are both larger than inner diameter of the middle part. Minimally invasive implanting of the esophagus stent is realized by the negativePoisson's ratio effect, and the esophagus wall is uniformly stressed in the stent dilating process, so that damage is effectively prevented, axial shrinkage is avoided and the stent is prevented fromdisplacing; meanwhile, by means of the negative Poisson's ratio structure, discomfort of a patient in an eating process can be relieved by the radial process of the stent while displacement is avoidedin the eating and swallowing process of the patient. The esophagus stent dilates automatically and gradually and is biodegradable under external motivation, and the problems of in-stent restenosis, difficulty in taking-out after implantation and the like are effectively solved.

Description

technical field [0001] The invention relates to a non-slip self-expandable degradable esophageal tube stent with a negative Poisson's ratio structure and its preparation. Background technique [0002] Esophageal tube stents commonly used in clinical practice can be roughly divided into three categories according to the use of materials: metal stents, polymer stents and composite stents; according to whether they are covered or not, they can be divided into bare stents, partially covered stents and fully covered stents. Stents are divided into permanent stents and degradable stents according to whether they are degradable. [0003] Metal stents have the longest clinical application history, from the early stainless steel stents to the mature memory alloy stents, which have the advantages of high strength and good shape retention, but at the same time have poor biocompatibility, which will cause secondary damage when taken out Trauma and other defects. [0004] Degradable st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82A61F2/90
Inventor 陈旻王富军王璐于杨闫顺顺王若斯阿依姆古丽·艾麦提赵帆吴斯蔚李超婧
Owner DONGHUA UNIV
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