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Application of gardenin in preparation of medicament for treating multiple sclerosis

A multiple sclerosis and geniposide technology, applied in the application field of geniposide in the preparation of drugs for the treatment of multiple sclerosis, can solve the problems of unclear mechanism of action and limitation of clinical application, etc., and achieve universality, The effect of obvious curative effect and few side effects

Active Publication Date: 2019-06-28
SHANDONG ANALYSIS & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese medicine with neuroprotective and anti-inflammatory effects has great potential in the treatment of MS. In recent years, some active ingredients such as tripterygium glycosides, matrine and sinomenine have been reported to slow down the disease process, but these ingredients The mechanism of action is not clear, which limits its clinical application

Method used

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  • Application of gardenin in preparation of medicament for treating multiple sclerosis
  • Application of gardenin in preparation of medicament for treating multiple sclerosis
  • Application of gardenin in preparation of medicament for treating multiple sclerosis

Examples

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Embodiment 1

[0037] 1 Experimental animals and reagents

[0038] Experimental animals: C57BL / 6 mice, female, 8 weeks old, weighing 18-22 g, provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. (23±1)°C, 12h alternating light and dark lighting, fed sterile common rat food, free access to water.

[0039] Experimental reagents: MOG 35-55 polypeptide, purchased from Mimotopes Peptides Company. Freund's complete adjuvant was purchased from Chondrex; pertussis toxin was purchased from List Biological Laboratories; geniposide was purchased from Jiangxi Linchuan Zhixin Biotechnology Company; ELISA kit was purchased from Wuhan Yunclone Technology Co., Ltd.; flow staining antibody and Pharmingen fixation / permeabilization kit were purchased from BD Company; X1R high-performance general-purpose desktop centrifuge was purchased from ThermoScientific Company; FACS Aria II flow cytometer was purchased from BD Company, USA.

[0040] 2 Experimental methods

[0041] 2.1 Establishmen...

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Abstract

The invention provides application of gardenin in preparation of a medicament for treating multiple sclerosis, and a pharmaceutical composition and health product comprising the gardenin. The composition contains a bioactive component and also contains a medicinal additive, wherein the bioactive component is the gardenin. The treatment effect of gardenin on multiple sclerosis is proved, and the dosage and action mechanism of gardenin treatment are provided, and a novel research direction is provided for developing the medicament which is used for treating multiple sclerosis and is obvious in research and development effect, small in side effect and low in price.

Description

technical field [0001] The invention belongs to the field of drugs for treating multiple sclerosis, and in particular relates to the application of geniposide in the preparation of drugs for treating multiple sclerosis. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Multiple sclerosis (MS) is the most common central nervous system (central nervous system, CNS) autoimmune disease. infiltrating and localized demyelinating lesions. Multiple sclerosis is one of the most common disabling neurological diseases among young and middle-aged adults in the world. Typical symptoms include: impaired mobility, visual impairment, fatigue and cognitive impairment. [0004] In recent y...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P25/28A61P37/02A61P29/00
Inventor 吕翠余迪冯金红郑婷侯召华魏云波韩贝贝
Owner SHANDONG ANALYSIS & TEST CENT
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