Stilbene compound originated from natural indigo and having anti-enteritis activity, and preparation method and application thereof

A technology of stilbenes and compounds, applied in ether preparation, organic chemistry, digestive system, etc., to achieve the effect of strong practicability, economical cost and simple extraction method

Active Publication Date: 2019-11-19
SHANDONG ANALYSIS & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no one has isolated and extracted stilbene polyphenols from Qingdai

Method used

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  • Stilbene compound originated from natural indigo and having anti-enteritis activity, and preparation method and application thereof
  • Stilbene compound originated from natural indigo and having anti-enteritis activity, and preparation method and application thereof
  • Stilbene compound originated from natural indigo and having anti-enteritis activity, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] The extraction method of 5-(2,4-dimethoxyphenethyl)benzene-1,2,3-triol (DP-I), comprises the steps:

[0078] 1) Pulverize Qingdai (10Kg), cold-soak with 95% ethanol (25L×3 times), combine the extracts, concentrate under reduced pressure, and obtain a crude extract (950g);

[0079] 2) Disperse the crude extract of Qingdai obtained in step 1) in water, and sequentially extract with petroleum ether (5L×3 times) and ethyl acetate (5L×3 times) to obtain ethyl acetate extract (420g);

[0080] 3) The ethyl acetate extract obtained in step 2) is passed through the D101 macroporous adsorption resin for impurity removal and adsorption, followed by elution with 30% ethanol (10L) and 85% (15L) ethanol, and the 85% ethanol eluate is collected, Concentrate under reduced pressure to obtain 80% ethanol eluate extract (195g);

[0081] 4) In step 3), elute the extract with 85% ethanol, separate it with normal phase silica gel, and use volume ratios of 15:1 (6 column volumes), 10:1 (6 co...

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Abstract

The invention relates to a stilbene compound originated from natural indigo and having anti-enteritis activity, and a preparation method and application thereof. A novel stilbene polyphenol compound is discovered in the invention, and the compound has substantial anti-colitis activity. Experiments have proved that DP-I has therapeutic effect on colitis; the administration dosage of DP-I for treatment is provided; and a new research direction is provided for the treatment of colitis.

Description

technical field [0001] The invention belongs to the technical field of stilbene polyphenol compounds and preparation methods thereof, and in particular relates to a stilbene compound with anti-colitis activity in Indigo Naturalis and an extraction method thereof. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease involving the ileum, rectum, and colon. Clinical manifestations include diarrhea, abdominal pain, and even bloody stools. The disease includes ulcerative colitis (UC) and Crohn's disease (CD). Ulcerative colitis is a continuous inflammation of the colonic mucosa and submucosa. The di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C43/23A61P1/00A61P1/04C07C41/34C07C41/36C07C41/38A61K31/09
CPCC07C43/23A61P1/00A61P1/04
Inventor 冯金红方磊魏云波薛安琪吕翠余迪
Owner SHANDONG ANALYSIS & TEST CENT
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