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Beta-levantenolide and preparation method thereof

A technology of basmaheptine and a compound, applied in the field of basmaheptine and its preparation, can solve the problems of less research on chemical components of oriental tobacco, achieve good anti-tobacco mosaic virus activity, broad application prospects, and structural novel effect

Inactive Publication Date: 2019-07-02
YUNNAN AGRICULTURAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yunxiang Basma No. 1 (YNOTBS1) is a new variety of oriental tobacco bred, mainly distributed in Yunna Baoshan, Lincang, Dehong and other production areas. At present, there are few studies on the chemical components of this oriental tobacco.

Method used

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  • Beta-levantenolide and preparation method thereof
  • Beta-levantenolide and preparation method thereof

Examples

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Effect test

Embodiment

[0026] The samples of this example were collected in the smoking area of ​​Dehong City, Yunnan Province.

[0027] The preparation of Basmagentin specifically comprises the following steps:

[0028] 1) 10 kg of the lower part tobacco leaves of No. 1 spice smoke cloud Xiang Basma which were dried in the air, pulverized, and passed through a 40-mesh sieve as a raw material.

[0029] 2) Soak the raw material obtained in step 1) with 10 times the amount (mass ratio) of analytically pure methanol for 10 hours, repeatedly extract 3 times, distill under reduced pressure until there is no alcohol smell, and concentrate to obtain 830 g of extract;

[0030] 3) Dissolve the extract obtained in step 2) in distilled water at a mass ratio of 1:1, extract with ethyl acetate, the mass ratio of the extract solution to ethyl acetate is 1:4, and recover the solvent until there is no ethyl acetate smell , Obtained 381 g of ethyl acetate fraction. The ethyl acetate part is mixed with silica gel a...

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Abstract

The invention relates to beta-levantenolide and a preparation method thereof, and belongs to the field of pharmaceutical and phytochemical technologies. The beta-levantenolide is obtained through separation. The preparation method comprises the following specific steps: collecting lower tobacco leaves of oriental tobacco YNOTBS1, drying in the shade and crushing, and sieving through a 40-mesh sieve as a raw material; immersing the raw material in a methanol solution, carrying out reduced pressure distillation, and concentrating to obtain an extract; extracting the extract with ethyl acetate, carrying out chromatographic separation through a silica gel column, separating through a thin-layer chromatography silica gel plate, and finally purifying through a high performance liquid chromatograph to obtain a pure compound. The beta-levantenolide is obtained from oriental tobacco YNOTBS1 through separation for the first time. The compound has a novel structure, and has various bioactivities,especially good activity against tobacco mosaic virus, thus providing important enlightenment for further research on the oriental tobacco plant as an anti-tobacco mosaic virus medicinal plant source. The compound can be used for research and development and preparation of anti-tobacco mosaic virus drugs.

Description

technical field [0001] The invention belongs to the technical field of medicine and phytochemistry, and in particular relates to a kind of basmagentin and its preparation method and application. Background technique [0002] Oriental tobacco (Oriental tobacco) is an annual or limited perennial herbaceous plant belonging to Solanaceae Nicotiana. my country is the country with the largest tobacco planting area and total output in the world. It is planted in both north and south of my country and has rich plant resources. The main function of oriental tobacco is to flavor and season mixed cigarettes. In addition to making cigarettes for people to smoke, it also has medicinal values ​​such as anti-cancer, anti-tumor, anti-oxidation, anti-ultraviolet radiation, and liver protection. [0003] At present, there are not many studies on the chemical components of oriental tobacco. Foreign scholars have conducted in vitro antibacterial activity research on the essential oil extracts o...

Claims

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Application Information

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IPC IPC(8): C07D493/10A01N43/90A01P1/00
CPCA01N43/90C07D493/10
Inventor 徐俊驹周文兵何承刚李江舟彭梦洁张立猛杨海林崔永和孟玉芳
Owner YUNNAN AGRICULTURAL UNIVERSITY
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