Tissue engineering transcatheter valve skirt body with regeneration function and preparation method thereof

Abstract

The invention discloses a tissue engineering transcatheter valve skirt body with a regeneration function. Perivalvular leakage generated after a transcatheter valve is implanted is better avoided. Thetissue engineering transcatheter valve skirt body is characterized in that by means of a tissue engineering method, seed cells are planted on a degradable polymer material support in vitro, a 0.1-0.3m sheet valve skirt is formed through culture, and the transcatheter valve in which the tissue engineering valve skirt is sewn is implanted in an aortic valve stenosis or insufficiency position. Thevalve skirt has growth, reconstruction and regeneration functions, the gaps between calcified plaques or autologous valve leaflets and the valve skirt can be autonomously filled, the degradation rateand the regeneration rate can be adjusted and controlled, and perivalvular leakage can be effectively avoided. According to the tissue engineering transcatheter valve skirt body, different material compositions and structures can be designed, good biocompatibility is achieved, and the tissue engineering transcatheter valve skirt body has broad application prospects in the field of transcatheter aortic valve implantation.

Description

technical field [0001] The invention is applied in the field of medical technology, and in particular relates to a novel tissue engineering transcatheter valve skirt and a preparation method thereof. Background technique [0002] With the aging population in our country, the number of degenerative valvular diseases, especially aortic valve stenosis and regurgitation, is gradually increasing, which significantly increases the social and economic burden. The traditional treatment of aortic valve stenosis is mechanical valve and bioprosthetic valve replacement, but the disadvantage of this surgical method is that it needs to open the chest, especially not suitable for the elderly. In recent years, transcatheter valve products with the advantages of low surgical risk, short recovery time, and no need for long-term anticoagulation have emerged, bringing hope to high-risk patients who need valve replacement. [0003] Under the guidance of imaging, the transcatheter valve is impla...

AI Technical Summary

Problems solved by technology

Although the skirt made of these materials can reduce the occurrence of paravalvular leakage to a certain extent, there are still problems such as damage after compression, decay and calcification after long-term implantation, and the gap between the valve annulus and the valve frame cannot be automatically adjusted.

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