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Anticoagulant for vacuum blood collection tube and preparation method thereof

A technology of vacuum blood collection tube and anticoagulant, which is applied in the field of medical in vitro diagnosis, can solve the problems of unstable anticoagulation of single sodium citrate, easy oxidation of citric acid, etc., and achieve the effect of improving accuracy

Pending Publication Date: 2019-08-09
JIANGXI YIKANG MEDICAL INSTR GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide an anticoagulant for vacuum blood collection tubes and a preparation method thereof. The technical problem to be solved is the problem that single sodium citrate anticoagulant is unstable and citric acid is easily oxidized in the determination of erythrocyte sedimentation rate.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] An anticoagulant for vacuum blood collection tubes, the mass percentage is: sodium citrate 2.5%, citrate 0.3%, ascorbic acid 0.1%, dissolved in water, stirred until there is no precipitation or crystallization, and adjust the pH to 6 , The water content is 96.1%. Add 1% diquaternary ammonium salt and mix well. Add 0.4ml of the prepared anticoagulant into the blood collection tube. After the anticoagulant is added to the blood collection tube, a vacuum blood collection tube with nitrogen as the protective gas is made, and the vacuum degree in the blood collection tube is -200Pa.

[0019] Sodium citrate, citric acid and ascorbic acid form a buffer solution to ensure the stability of the citrate ion concentration in the liquid. During the erythrocyte sedimentation rate determination, the citrate ion is ionized and complexed with calcium to ensure the accuracy of the test results;

[0020] Ascorbic acid acts as an antioxidant, which can prevent citrate ions from being oxidized...

Embodiment 2

[0025] An anticoagulant for vacuum blood collection tubes, the mass percentage will be: sodium citrate 3.5%, citrate 0.1%, ascorbic acid 0.2%, dissolved in water, stirred until there is no precipitation or crystallization, adjust the pH to 6.7, of which the water content is 95.7%. Add 0.5% double quaternary ammonium salt and mix well. Add 0.4ml of the prepared anticoagulant into the blood collection tube. After the anticoagulant is added to the blood collection tube, a vacuum blood collection tube with nitrogen as the protective gas is made, and the vacuum degree in the blood collection tube is -190Pa.

[0026] Sodium citrate, citric acid and ascorbic acid form a buffer solution to ensure the stability of the citrate ion concentration in the liquid. During the erythrocyte sedimentation rate determination, the citrate ion is ionized and complexed with calcium to ensure the accuracy of the test results;

[0027] Ascorbic acid acts as an antioxidant, which can prevent citrate ions f...

Embodiment 3

[0032] An anticoagulant for vacuum blood collection tubes, the mass percentage will be: sodium citrate 3.0%, citric acid 0.2%, ascorbic acid 0.1%, dissolved in water, stirred until there is no precipitation or crystallization, adjust the pH to 6.3, of which the water content is 96.2%. Add 0.5% double quaternary ammonium salt and mix well. Add 0.4ml of the prepared anticoagulant into the blood collection tube. After the anticoagulant is added to the blood collection tube, a vacuum blood collection tube with nitrogen as the protective gas is made, and the vacuum degree in the blood collection tube is -220Pa.

[0033] Sodium citrate, citric acid and ascorbic acid form a buffer solution to ensure the stability of the citrate ion concentration in the liquid. During the erythrocyte sedimentation rate determination, the citrate ion is ionized and complexed with calcium to ensure the accuracy of the test results;

[0034] Ascorbic acid acts as an antioxidant, which can prevent citrate io...

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Abstract

The invention belongs to the field of medical in-vitro diagnosis, and particularly relates to an anticoagulant for a vacuum blood collection tube. The anticoagulant is prepared from the following rawmaterials in percentage by mass: 2.5 to 3.5 percent of sodium citrate, 0.1 to 0.3 percent of citric acid, 0.1 to 0.2 percent of ascorbic acid, 0.5 to 1 percent of biquaternary ammonium salt and 95.6 to 96.8 percent of water. Sodium citrate, citric acid and ascorbic acid form a buffer solution, and meanwhile, ascorbic acid and nitrogen can prevent citrate ions from being oxidized, so that the stability of the concentration of the citrate ions in the liquid is ensured, and the accuracy of the erythrocyte sedimentation rate measurement is improved.

Description

Technical field [0001] The invention belongs to the field of medical in vitro diagnostics, and specifically relates to an anticoagulant used in a vacuum blood collection tube. Background technique [0002] The erythrocyte sedimentation rate determination is a routine blood test commonly used in clinical practice. It has certain reference value for the diagnosis and treatment of various diseases such as inflammation and active disease. ESR determination usually uses sodium citrate as an anticoagulant, which is mixed with blood in a certain proportion to have an anticoagulant effect. A single sodium citrate has the problem of unstable anticoagulation and poor effect. At the same time, sodium citrate is easily oxidized, and the concentration of citrate decreases after oxidation, which will affect the accuracy of the test results. Summary of the invention [0003] The purpose of the present invention is to provide an anticoagulant for vacuum blood collection tubes and a preparation m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28
CPCG01N1/28
Inventor 胡鹏朱元郴
Owner JIANGXI YIKANG MEDICAL INSTR GROUP
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