A kind of composition, kit and method for detecting anti-lung cancer natural antibody
A natural antibody and composition technology, applied in the field of immunology, can solve the problem of high risk of tumors, and achieve the effect of moderate cost, high precision and simple operation
Active Publication Date: 2022-07-01
QINGDAO HAILANSHEN BIOTECH
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Based on this, it is speculated that the risk of developing tumors in people with natural antibody deficiency may be significantly higher than that in normal people
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[0064] 1. Sample collection
[0065] Plasma samples from 213 patients with non-small cell lung cancer (squamous epithelial lung cancer and adenoepithelial lung cancer) before surgical treatment and 200 healthy human plasma samples were collected for the detection of plasma NALCIgG levels. All plasma samples were stored at -80°C before operation. It was verified that the storage time did not exceed two years, and there was no repeated freezing and thawing (the number of times did not exceed 3 times).
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Abstract
The present invention relates to a composition for detecting anti-lung cancer natural antibodies (NALC), a kit made from the composition, a method for detecting the concentration of NALC in a sample using the composition or the kit, and the composition or the reagent Application of the cassette in NALC detection of samples. The present invention utilizes three kinds of linear antigen polypeptides that are completely complementary to the target NALC to realize the qualitative and quantitative detection of NALC in the sample, and can be used for predicting the risk of lung cancer and diagnosing lung cancer early.
Description
technical field [0001] The invention belongs to the technical field of immunology, relates to three kinds of peptide antigens, can be used for preparing an enzyme-linked immunosorbent assay (ELISA) antibody detection kit, and is used for detecting anti-lung cancer natural antibodies (Natural Antibody) in human blood. antibody for lung cancer, NALC) concentration. Background technique [0002] Malignant tumors are one of the most important killers that threaten the whole human health. Due to the continuous existence of environmental pollution such as smog and haze, the incidence of major cancers in the Chinese population is increasing year by year. According to statistics, the average annual incidence of cancer in my country is as high as 3 / 1000 or more. Early tumor treatment methods, such as surgical resection or radiation therapy, have been developed relatively maturely, which can significantly prolong the survival time of patients. However, how to predict the risk of tu...
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IPC IPC(8): C07K14/71G01N33/68
CPCG01N33/6854G01N33/57423G01N33/57488G01N2333/715G01N2333/71G01N2333/4725
Inventor 韩传伟张萱徐宏海
Owner QINGDAO HAILANSHEN BIOTECH