Preparation and application of a traditional Chinese medicine granule for treating or preventing influenza virus infection in children

A technology of influenza virus infection and traditional Chinese medicine granules, which is applied to antiviral agents, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve correct syndrome differentiation, reduce complications, and increase stability.

Active Publication Date: 2021-09-28
WUXI JIYU SHANHE PHARM CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] The object of the present invention is to provide a Chinese medicine preparation that is convenient to take, good in tolerance, good in taste and remarkable in effect in treating or preventing influenza virus infection in children, preferably Chinese medicine granules, which overcome the disadvantages of many adverse reactions of western medicines. Defects, taking advantage of the dialectical treatment of traditional Chinese medicine, the curative effect is remarkable, and because of its good taste, it is easier to be accepted by children patients

Method used

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  • Preparation and application of a traditional Chinese medicine granule for treating or preventing influenza virus infection in children

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 formula and preparation method

[0036] Recipe: Honeysuckle 200g, Forsythia 50g, Bupleurum 60g, Mint 30g, Honey-roasted Ephedra 60g, Huoxiang 50g, Bitter almond 100g, Honey-roasted Baibu 400g, Fried cocklebur 50g, Angelica 60g, Gypsum 150g, perilla leaves 50g, raw licorice 30g.

[0037] Preparation: decoct the above-mentioned forsythia, bupleurum, peppermint, and Huoxiang to extract volatile oil, steam distill, filter the medicinal liquid, and collect the last remaining medicinal residues. Among them, the volatile oil is clathrated with hydroxypropyl-β-cyclodextrin, the ratio of volatile oil and hydroxypropyl-β-cyclodextrin is 1:8, the clathrate temperature is 55° C., and the clathrate time is 3 hours. The remaining 9 medicinal materials such as honeysuckle and the above-mentioned dregs are decocted with water for three times, the first time is 1.5 hours, the second time is 1 hour, and the third time is 1 hour. Combine the decoctions three times, filter, a...

Embodiment 2

[0038] Embodiment 2 formula and preparation method

[0039] Recipe: Honeysuckle 250g, Forsythia 100g, Bupleurum 150g, Mint 80g, Honey-roasted Ephedra 120g, Huoxiang 60g, Bitter almond 60g, Honey-roasted Baibu 300g, Fried cocklebur 60g, Angelica 100g, Gypsum 120g, perilla leaves 100g, raw licorice 60g.

[0040] Preparation: decoct the above-mentioned forsythia, bupleurum, peppermint, and Huoxiang to extract volatile oil, steam distill, filter the medicinal liquid, and collect the last remaining medicinal residues. Among them, the volatile oil is clathrated with hydroxypropyl-β-cyclodextrin, the ratio of volatile oil and hydroxypropyl-β-cyclodextrin is 1:8, the clathrate temperature is 55° C., and the clathrate time is 3 hours. The remaining 9 medicinal materials such as honeysuckle and the above-mentioned dregs are decocted with water for three times, the first time is 1.5 hours, the second time is 1 hour, and the third time is 1 hour. Combine the decoctions three times, filte...

Embodiment 3

[0041] Example 3 Observation on Curative Effect of Treating Children's Influenza

[0042] General information: There are a total of 96 children in this case, all of whom were diagnosed with influenza at the outpatient clinic of Wuxi Hospital of Traditional Chinese Medicine. They were randomly divided into a treatment group and a control group, with 48 cases in each group. The treatment group consisted of 48 cases, including 23 males and 25 females; aged 2 to 12 years, with an average (6.0±2.3) years old; the course of disease was 1 to 2 days. The control group consisted of 48 cases, 25 males and 23 females; aged 2 to 14 years, with an average of (6.8±1.7) years old; disease duration 1 to 2 days. There was no significant difference between the two groups in terms of gender, age, and course of disease (P>0.05), and they were comparable.

[0043] Inclusion criteria: ①The Ministry of Health issued the "Influenza Diagnosis and Treatment Standards and Treatment Guidelines (2016 Edi...

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Abstract

The invention discloses the preparation and application of a traditional Chinese medicine granule for treating or preventing influenza virus infection in children. The traditional Chinese medicine granule is made of the following traditional Chinese medicines in the weight ratio as raw materials: 10-25 parts of honeysuckle, 5-20 parts of forsythia 5-15 parts of bupleurum, 3-10 parts of mint, 3-12 parts of honey-roasted ephedra, 3-10 parts of Huoxiang, 8-15 parts of bitter almond, 20-40 parts of honey-roasted baebu, fried cocklebur 4‑8 parts, 5‑12 parts of Angelica dahurica, 10‑20 parts of raw gypsum, 5‑15 parts of perilla leaves, 3‑9 parts of raw licorice.

Description

technical field [0001] The invention belongs to the technical field of medicine and pharmacy, and relates to the preparation and application of traditional Chinese medicine granules for treating or preventing influenza virus infection in children. Background technique [0002] Influenza is an acute respiratory infectious disease caused by influenza virus. Due to the high variability of influenza virus, the population is generally susceptible to outbreaks, and a small number of cases progress rapidly and may cause death due to severe complications. Timely treatment and prevention of antiviral drugs can not only reduce flu symptoms, shorten the course of the disease, but also prevent severe flu complications. [0003] Children are susceptible to influenza and high-risk of severe cases. During the influenza epidemic season, more than 40% of preschool children and 30% of school-age children may suffer from influenza. Influenza epidemics can also cause a large number of school-a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/904A61K47/69A61P11/00A61P31/16A61K33/06
CPCA61K33/06A61K36/17A61K36/232A61K36/233A61K36/28A61K36/355A61K36/484A61K36/532A61K36/534A61K36/535A61K36/634A61K36/736A61K36/904A61K2236/331A61K2236/39A61K47/6951A61P11/00A61P31/16A61K2300/00
Inventor 戴亚妮於江华朱音毛菊红邹济高
Owner WUXI JIYU SHANHE PHARM CO LTD
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