Biomarker metabolic pathway, and analysis method and application

A biomarker and pathway technology, applied in the field of functional analysis of metabolic biomarkers in diseases, can solve problems such as incompletely clear functions of metabolic biomarkers in depression

CN110286233AActive Publication Date: 2019-09-27SHANXI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2019-09-27

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Abstract

The invention belongs to the technical field of functional analysis methods of disease metabolism biomarkers, and provides a biomarker metabolic pathway and an analysis method. The metabolic biomarker is stearic acid, phytosphingosine, glycine, glutamine and phospholipids; an acting target spot of the metabolic biomarker is a target protein related to a depression nervous system, immune response and endocrine; and the metabolic pathway is a PI3K-Akt signaling pathway, an mTOR signaling pathway, an MAPK signaling pathway, an erbB signaling pathway, a neurenergen signaling pathway, an Rap1 signaling pathway and an Ras signaling pathway. A functional network analysis method suitable for depression characteristics is established, and the clinical application of these biomarkers helps to optimize the diagnosis of depression, and can provide some valuable clues for the subsequent depression network function researches.
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Description

technical field

[0001] The invention belongs to the technical field of functional analysis methods of disease metabolic biomarkers, and relates to a biomarker metabolic pathway and its analysis method and application, in particular to a depression metabolic biomarker metabolic pathway and analysis method based on network pharmacology. Background technique

[0002] Metabolomics is a rapidly developing omics technology following genomics, transcriptomics and proteomics, and is an important part of systems biology. Integrality is the basic point of view of metabolomics theory, which mainly uses nuclear magnetic resonance, mass spectrometry and other technical means to study the changes and laws of metabolites after biological systems are stimulated or disturbed. Changes in the levels of these metabolites are closely related to related metabolic pathways. By studying changes in metabolite levels and related metabolic pathways, we can understand the changes in the body as a whole...

Examples

Embodiment Construction

[0022] In order to further describe the present invention in detail, the following specific examples are given, but only to illustrate the present invention, not to limit the scope of the present invention.

[0023] 1. Metabolic biomarkers-enzyme network analysis of depression

[0024] Information and structures of identified metabolic biomarkers of depression were obtained from the Human Metabolomics Database (HMDB), and the structures of these compounds were downloaded from PubChem. HMDB also collected enzymes related to metabolic biomarkers, and the functional categories of these proteins were extracted from the UniProt database. The network centrality of nodes (metabolic biomarkers and enzymes) was calculated with the network analyzer module of Cytoscape. Centrality is used to evaluate the importance of nodes in the network. In an undirected network, degree is defined as the number of neighboring nodes. For example, the degree to which a node is an enzyme is the number ...