Safflower carefree preparation for treating hyperplasia of mammary glands, preparation method therefor and application of safflower carefree preparation

A technology of breast hyperplasia and safflower, applied in the field of safflower Xiaoyao preparation for treating mammary gland hyperplasia and its preparation, can solve problems such as skin allergies, side effects, anaphylactic shock, etc., achieve the goal of reducing impurity content, reducing side effects, and good therapeutic effect Effect

Active Publication Date: 2019-11-29
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent application CN 104958693 A discloses a traditional Chinese medicine for treating mammary gland hyperplasia. -20 parts, Angelica 5-15 parts, Radix Paeoniae Rubra 5-15 parts, Bupleurum 5-15 parts, Curcuma 10-20 parts, due to the limitations of their treatment methods, the extraction of active ingredients is not sufficient, and has certain side effects , the therapeutic effect still needs to be improved
[0005] Chinese patent application CN 1055623 A discloses a Chinese patent medicine for the treatment of hyperplasia of mammary glands in women. , Poria

Method used

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  • Safflower carefree preparation for treating hyperplasia of mammary glands, preparation method therefor and application of safflower carefree preparation
  • Safflower carefree preparation for treating hyperplasia of mammary glands, preparation method therefor and application of safflower carefree preparation
  • Safflower carefree preparation for treating hyperplasia of mammary glands, preparation method therefor and application of safflower carefree preparation

Examples

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Effect test

Embodiment 1

[0036] In the present example, the safflower Xiaoyao preparation for treating mammary gland hyperplasia includes the following raw materials in parts by weight: 32 parts of angelica, 130 parts of white peony root, 50 parts of Atractylodes macrocephala, 127 parts of poria cocos, 140 parts of safflower, 28 parts of saponins 110 parts of Bupleurum bupleurum, 65 parts of mint, and 55 parts of licorice.

[0037] The preparation method of the safflower Xiaoyao preparation for the treatment of mammary gland hyperplasia comprises the following steps:

[0038] (1) After crushing safflower, licorice, and Bupleurum bupleurum, add water to mix and extract, raise the temperature to 80°C for extraction for 1.5 hours, and then boil for 25 minutes; obtain water extract A and medicinal residue 1;

[0039] Take macroporous adsorption resin chromatography column: the upper layer is AB-8, the middle layer is NKA and the lower layer is NKA-9, wherein the thickness ratio of AB-8, NKA, NKA-9 is 1:2:...

Embodiment 2

[0047] A safflower Xiaoyao preparation for treating mammary gland hyperplasia, comprising the following raw materials in parts by weight: 18 parts of Angelica sinensis, 100 parts of Radix Paeoniae Alba, 55 parts of 140 parts of Bupleurum leaf, 85 parts of mint, 20 parts of licorice;

[0048] The preparation method of the safflower Xiaoyao preparation for the treatment of mammary gland hyperplasia comprises the following steps:

[0049] (1) After crushing safflower, licorice, and Bupleurum chinensis, add water to mix and extract, raise the temperature to 75°C for extraction for 1 hour, and then boil for 30 minutes to obtain water extract A and medicinal residue 1;

[0050] Take macroporous adsorption resin chromatography column: the upper layer is AB-8, the middle layer is NKA and the lower layer is NKA-9, wherein the thickness ratio of AB-8, NKA, NKA-9 is 1:1:1 ; Soak the chromatographic column in ethanol for 20min, then soak in water for 2h;

[0051] The water extract A is ...

Embodiment 3

[0058] A safflower Xiaoyao preparation for treating mammary gland hyperplasia, comprising the following raw materials in parts by weight: 67 parts of angelica, 150 parts of white peony, 30 parts of Atractylodes macrocephala, 105 parts of poria cocos, 160 parts of safflower, 35 parts of saponins, bamboo 80 parts of Bupleurum leaf, 45 parts of mint, 75 parts of licorice;

[0059] The preparation method of the safflower Xiaoyao preparation for the treatment of mammary gland hyperplasia comprises the following steps:

[0060] (1) After crushing safflower, licorice, and Bupleurum bupleurum, add water to mix and extract, raise the temperature to 90°C for extraction for 2 hours, and then boil for 20 minutes to obtain water extract A and medicinal residue 1;

[0061] Take macroporous adsorption resin chromatography column: the upper layer is AB-8, the middle layer is NKA and the lower layer is NKA-9, wherein the thickness ratio of AB-8, NKA, NKA-9 is 1:2:2 ; The chromatographic colum...

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Abstract

The invention belongs to the fields of preparation and application of safflower carefree tablets and particularly relates to a safflower carefree preparation for treating hyperplasia of mammary glandsand a preparation method therefor. The safflower carefree preparation comprises the following raw materials in parts by weight: 18-67 parts of radix angelicae sinensis, 100-150 parts of radix paeoniae alba, 30-55 parts of rhizoma atractylodis alba, 105-135 parts of poria cocos, 110-160 parts of safflowers, 20-35 parts of gleditsia sinensis lamarck, 80-140 parts of herba bupleuri, 45-85 parts of herba menthae and 20-75 parts of radix glycyrrhizae. The drugs have a relatively good treatment effect on the hyperplasia of mammary glands; and the safflower carefree preparation prepared by the specific preparation method can excellently exert effective actions of the drugs and can play a very good role in regulating female endocrine secretion.

Description

technical field [0001] The invention belongs to the field of preparation and application of safflower xiaoyao tablets, and in particular relates to a safflower xiaoyao preparation for treating mammary gland hyperplasia, a preparation method and application thereof. Background technique [0002] Breast hyperplasia, also known as breast dysplasia, is a common breast disease with breast lumps, breast pain, and nipple discharge as the main symptoms. It is a degenerative and progressive lesion in the structure of mammary ducts and lobules [1]. Mammary gland hyperplasia not only does not belong to the category of tumors, but also does not belong to the scope of inflammation, but changes in the structure of breast lobules and breast ducts [2]. According to the pathology, it can be divided into simple epithelial hyperplasia of the breast, cystic hyperplasia of the breast and breast adenosis. The main clinical features of hyperplasia of the mammary glands are lumps in the breast and...

Claims

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Application Information

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IPC IPC(8): A61K36/65A61K36/71A61P15/14
CPCA61K36/076A61K36/232A61K36/233A61K36/284A61K36/286A61K36/483A61K36/484A61K36/534A61K36/65A61K36/71A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61P15/14A61K2300/00
Inventor 陈梁李小锋刘厚权夏淑英胡吉忠张俊英张金良周朝忠毛金娣
Owner JIANGXI POZIN PHARMA
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