Method for making ascending aortic aneurysm animal model

An ascending aortic aneurysm, animal model technology, applied in medical science, veterinary instruments, veterinary surgery, etc., can solve the problems of affecting reliability, low tumor formation rate of animal models, long tumor formation time, etc., and achieve widespread promotion. Application, preparation method is simple and easy, and the effect of high tumor formation rate
CN110547249AInactive Publication Date: 2019-12-10SUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU UNIV
Publication Date
2019-12-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a method for making an ascending aortic aneurysm animal model. The method comprises the following steps: (1) ligating the root of the ascending aorta of a mouse by using a cushion needle with the outer diameter of 1.0-1.6 mm; (2) feeding the mouse undergoing a ligation operation with an oral rehydration salt solution containing tramadol hydrochloride capsules. The making method is simple and feasible, can be widely applied and popularized, and is high in tumor forming rate and short in tumor forming time.
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Description

technical field

[0001] The invention specifically relates to a preparation method of an ascending aortic aneurysm animal model. Background technique

[0002] Over the past 30 years, the prevalence of thoracic aortic aneurysm (TAA) has increased as the aging population has increased. The incidence of TAA in people over the age of 65 is approximately 3-4%, of which 60% are ascending aortic aneurysms (ATAA), predisposing patients to life-threatening complications such as aortic dissection or rupture. Current studies have shown that the formation mechanism of TAA is different from that of abdominal aortic aneurysm (AAA), and most thoracic aortic aneurysms are degenerative lesions. Pathologically, TAA exhibits matrix degeneration, loss of vascular smooth muscle, disruption of matrix elastic fibers, proteoglycan deposition, and infiltration of inflammatory cells (macrophages and T lymphocytes) in the aortic wall. During this process, accompanied by changes in the expression of m...

Claims

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