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A diagnostic kit for non-obstructive azoospermia

A non-blocking technology for azoospermia, applied in the field of molecular biology, can solve the problems of laboriousness, affecting the patient's condition and treatment progress, and time-consuming NOA detection process, so as to achieve the effect of improving accuracy and treatment progress, and better understanding

Active Publication Date: 2022-05-27
ARMY MEDICAL UNIV
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Problems solved by technology

[0004] This application provides a diagnostic box for non-obstructive azoospermia to solve the problem that the existing NOA detection process is time-consuming, laborious, and seriously affects the patient's condition and treatment progress

Method used

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  • A diagnostic kit for non-obstructive azoospermia
  • A diagnostic kit for non-obstructive azoospermia
  • A diagnostic kit for non-obstructive azoospermia

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Embodiment Construction

[0023] The SOX family is a class of developmental nuclear transcription factors, a gene superfamily of genes related to the male sex determining gene SRY (sex determining region of Chr Y), and its members have a highly conserved DNA binding domain (HMG-box). Existing studies have shown that SOX genes are widely involved in embryonic development, sex determination, organ formation and tumorigenesis. SOX30 (SRY box containing gene 30) is the only member of the H subfamily of the SOX gene family, which plays a very important role in spermatogenesis.

[0024] Acquisition of clinical samples: 15 cases of OA puncture testicular tissue with normal spermatogenicity in Daping Hospital and 58 cases of NOA puncture testicular tissue with detailed pathological information were selected as liquid nitrogen preservation tissue and paraffin specimen tissue. °C refrigerator. Among them, the inclusion criteria for OA were patients with normal tissue morphology, normal spermatogenesis by punctu...

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Abstract

In this application, the methylation status of SOX30 gene and the expression levels of mRNA and encoded protein in normal control OA and NOA punctured testis tissues were detected. The detection results showed that SOX30 gene was specifically hypermethylated and expressed silently in NOA punctured testis tissues. Based on the above test results, this application provides a diagnostic box for non-obstructive azoospermia, which can help clinical NOA patients formulate effective treatment plans to improve accuracy and treatment progress, and at the same time help to better understand the cause of NOA and formulate risks. Evaluation and early diagnosis are of great significance.

Description

technical field [0001] The present application relates to the technical field of molecular biology, in particular to a diagnostic kit for non-obstructive azoospermia. Background technique [0002] As an important disease affecting human reproduction, infertility has become a serious medical health problem and a serious social problem worldwide, and has received widespread attention. The World Health Organization (WHO) predicts that infertility will become the third largest disease after cancer and cardiovascular disease among diseases affecting human life and health. According to the latest statistics from WHO, the number of couples suffering from infertility in the world is about 80 million, of which male patients account for about 50%, and the proportion of male infertility is increasing year by year. In my country, with the opening of the national "two-child" policy, the problem of male infertility is particularly prominent. The etiology of male infertility is very comp...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883G01N33/68G01N33/577
CPCC12Q1/6883G01N33/6893G01N33/577C12Q2600/154G01N2800/34
Inventor 韩飞刘晋祎曹佳孙磊刘文斌张中豪陈卿
Owner ARMY MEDICAL UNIV
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