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Diagnosis box for non-obstructive azoospermia (NOA)

A non-blocking technology for azoospermia, applied in the field of molecular biology, can solve the problems of laborious, time-consuming NOA detection process, affecting the patient's condition and treatment progress, etc.

Active Publication Date: 2019-12-17
ARMY MEDICAL UNIV
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Problems solved by technology

[0004] This application provides a diagnostic box for non-obstructive azoospermia to solve the problem that the existing NOA detection process is time-consuming, laborious, and seriously affects the patient's condition and treatment progress

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  • Diagnosis box for non-obstructive azoospermia (NOA)

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Embodiment Construction

[0023] The SOX family is a class of developmental nuclear transcription factors. It is a gene superfamily composed of genes related to the male sex determining gene SRY (sex determining region of Chr Y), and its members have a highly conserved DNA binding domain (HMG-box). Existing studies have shown that SOX genes are widely involved in embryonic development, sex determination, organ formation and tumorigenesis. SOX30 (SRY box containing gene 30) is the only member of the H subfamily of the SOX gene family, which plays a very important role in sperm formation.

[0024] Acquisition of clinical samples: 15 cases of OA puncture testicular tissues with normal spermatogenicity and 58 cases of NOA puncture testicular tissues with detailed pathological information were selected from Daping Hospital. ℃ refrigerator. Among them, the inclusion criteria for OA are patients with normal tissue morphology, normal spermatogenesis in punctured testicular tissue, and patients who can bear ch...

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Abstract

The invention discloses a diagnosis box for non-obstructive azoospermia (NOA). According to the diagnosis box, the methylation states of SOX30 genes and the expression levels of mRNA and coding proteins in naturally compared obstructive azoospermia (OA) and NOA punctured testis tissue are detected. The detection result shows that the SOX30 genes are subjected to specific hypermethylation and lossof expression in the NOA punctured testis tissue. Based on the detection result, the invention provides the diagnostic box for NOA, clinical NOA patients can be helped to formulate effective treatmentschemes to improve precision and accelerate the treatment progress, and meanwhile the diagnosis box has important significance for better understanding of NOA nosogenesis, formulating risk assessmentand early diagnosis.

Description

technical field [0001] The application relates to the technical field of molecular biology, in particular to a diagnostic box for non-obstructive azoospermia. Background technique [0002] As an important disease affecting human reproduction, infertility has become a serious medical health problem and a serious social problem worldwide, and has attracted widespread attention. The World Health Organization (WHO) predicts that infertility will become the third largest disease after tumors and cardiovascular diseases among diseases affecting human life and health. According to the latest statistics from WHO, the number of infertile couples worldwide is about 80 million, of which male patients account for about 50%, and the proportion of infertility caused by males is increasing year by year. In my country, with the opening of the national "two-child" policy, the problem of male infertility is particularly prominent. The etiology of male infertility is very complex, and the pa...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883G01N33/68G01N33/577
CPCC12Q1/6883G01N33/6893G01N33/577C12Q2600/154G01N2800/34
Inventor 韩飞刘晋祎曹佳孙磊刘文斌张中豪陈卿
Owner ARMY MEDICAL UNIV
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