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Polyamidoamine structure polymer for secondary antibody detection system and preparation method thereof

A technology of polyamidoamine and polymer, which is applied in the field of polyamidoamine structure polymer and its preparation, can solve the problems of inability to improve sensitivity, high cost of use, high price, etc., and overcome the large steric hindrance and product cost Low, good affinity effect

Inactive Publication Date: 2019-12-31
百盛(广州)生物制品有限公司
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Problems solved by technology

[0015] In order to solve the problem that most of the "enzyme-polymer-antibody" detection systems (secondary antibodies) used in China rely on imports, are expensive, use high costs, and cannot improve sensitivity, polyamidoamine structures for secondary antibody detection systems are provided. Polymer and its preparation method

Method used

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  • Polyamidoamine structure polymer for secondary antibody detection system and preparation method thereof
  • Polyamidoamine structure polymer for secondary antibody detection system and preparation method thereof
  • Polyamidoamine structure polymer for secondary antibody detection system and preparation method thereof

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Embodiment Construction

[0037] In order to solve the problem that most of the "enzyme-polymer-antibody" detection systems (secondary antibodies) used in China rely on imports, are expensive, use high costs, and cannot improve sensitivity, polyamidoamine structures for secondary antibody detection systems are provided. Polymers and methods for their preparation.

[0038] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments It is a part of embodiments of the present invention, but not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

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Abstract

The invention belongs to the technical field of secondary antibody detection systems, and specifically relates to a polyamidoamine structure polymer for a secondary antibody detection system and a preparation method thereof. The preparation method comprises the steps of carrying out amidation reaction on a -NH2 functional group on a dendritic polyamidoamine structure and -COOH functional groups onbinding enzyme protein and immune globulin, so that protein molecules are tightly combined on a polyamidoamine skeleton structure, and the concentration of protein per unit volume is increased. The secondary antibody polymer prepared according to the invention is higher in detection sensitivity, lower in background and lower in cost than products on the market, and has wide market application prospect and remarkable substantive features.

Description

technical field [0001] The invention relates to the technical field of secondary antibody detection systems, in particular, to a polyamidoamine structure polymer used in a secondary antibody detection system and a preparation method thereof. Background technique [0002] At present, there are two main types of immunohistochemical ready-to-use secondary antibody detection systems used by domestic scientific research institutions and clinical diagnostic institutions. The second antibody detection system (biotin detection system) that amplifies the signal; the other is a secondary antibody detection system that amplifies the signal by coupling multiple antibodies and enzymes on the polymer ("enzyme-polymer- Antibody" detection system). The biotin detection system sometimes produces false positive results due to the interference of endogenous biotin in the tissue to be tested, which affects the accuracy of the results. Therefore, the application of this secondary antibody detec...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68C08G73/02
CPCC08G73/028G01N33/6854
Inventor 谭瑞政
Owner 百盛(广州)生物制品有限公司
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