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Gd-based magnetic resonance contrast agent nanomaterial constructed based on MOF-808 as well as preparation method and application of nanomaterial

A technology of MOF-808 and MOF-808-DTPA, which is applied in the field of constructing Gd-based magnetic resonance contrast agent nanomaterials based on MOF-808 and their preparation, can solve the problems of contrast agent toxicity and the like, and achieve a simple, green and pollution-free synthesis process. cost effect

Inactive Publication Date: 2020-01-03
SHANGHAI NORMAL UNIVERSITY
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Problems solved by technology

However, these nanoparticle-based T 1 Contrast agents still have toxicity concerns

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  • Gd-based magnetic resonance contrast agent nanomaterial constructed based on MOF-808 as well as preparation method and application of nanomaterial
  • Gd-based magnetic resonance contrast agent nanomaterial constructed based on MOF-808 as well as preparation method and application of nanomaterial
  • Gd-based magnetic resonance contrast agent nanomaterial constructed based on MOF-808 as well as preparation method and application of nanomaterial

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preparation example Construction

[0046] The above preparation method for constructing Gd-based magnetic resonance contrast agent nanomaterials based on MOF-808 comprises the following steps:

[0047] (1) Activate MOF-808;

[0048] (2) Add the activated MOF-808 to the aqueous solution of diethylenetriaminepentaacetate under an inert gas atmosphere to react;

[0049] (3) Solid-liquid separation, collection of particles, to obtain MOF-808-DTPA;

[0050] (4) Dissolve MOF-808-DTPA in an aqueous solution, add the aqueous solution of gadolinium source to react, after the reaction, separate the solid and liquid, collect the particles, and obtain the Gd-based magnetic resonance contrast agent nanomaterial based on MOF-808 .

[0051] The preferred MOF-808 of the present invention is prepared by a solvothermal method, comprising the following steps:

[0052] (a) adding zirconium oxychloride octahydrate, trimesic acid, N-N-dimethylformamide and formic acid in the reactor to carry out solvothermal reaction;

[0053] (...

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Abstract

The invention relates to a Gd-based magnetic resonance contrast agent nanomaterial constructed based on MOF-808 as well as a preparation method and application of the nanomaterial. The T1-weighted contrast agent material with a high relaxation rate is obtained by grafting Gd ions having a T1-weighted MRI effect onto MOF-808-DTPA, wherein the MOF-808-DTPA is obtained by using DTPA to replace a zirconium cluster group on the MOF-808. Compared with the prior art, the method provided by the invention designs and successfully prepares the Gd-based magnetic resonance contrast agent nanomaterial withthe high relaxation rate, the MOF-808-DTPA-Gd nanoparticles can stabilize DTPA-Gd molecules, reduce the release of the Gd ions and improve safety; and the MOF-808-DTPA-Gd nanoparticles have good water solubility and the high relaxation rate, and can be used as a T1 contrast agent to improve the accuracy of tumor diagnosis.

Description

technical field [0001] The invention relates to the technical fields of inorganic nanomaterials and molecular imaging, in particular to a nanomaterial for constructing a Gd-based magnetic resonance contrast agent based on MOF-808 and its preparation method and application. Background technique [0002] Magnetic resonance imaging, because of its visualization and intuition, is widely used in the field of science and technology, especially in the field of biological imaging, and is a good imaging method. MRI is a non-invasive diagnostic imaging technique that can obtain anatomical, physiological and molecular information of living organisms without harming the living organisms. At the same time, it has sufficient penetration depth, which is enough to image the whole human body. Its spatial resolution depends on the strength of the magnetic field, and the lowest can reach 10 μm (the clinical resolution is generally selected as ~1mm). It is widely used in the early specific diag...

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Application Information

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IPC IPC(8): A61K49/10A61K49/18
CPCA61K49/106A61K49/1833
Inventor 杨仕平林焦敏陈亚南安璐田启威
Owner SHANGHAI NORMAL UNIVERSITY
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