Application of light controlled neutrophilic granulocytes in medicines for treating cancers

A technology of neutrophils and light regulation, applied in the fields of application, animal cells, and drug combinations, can solve the problems of inability to change the immunosuppressive microenvironment of solid tumors and limited curative effect, so as to improve the phenomenon of immunosuppression and improve the therapeutic effect. effect of effect
CN110755449AInactive Publication Date: 2020-02-07SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SOUTH UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA
Publication Date
2020-02-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of light controlled neutrophilic granulocytes in medicines for treating cancers. The light controlled neutrophilic granulocytes can express cytokines for recruitingand amplifying immune cells under a light condition. The performance that neutrophilic granulocytes can be recruited by tumors is utilized, a light controlled cytokine system is expressed in the neutrophilic granulocytes and is used for in-vitro verifying that levels of different cytokines released by modified cells and promoting and inhibiting effects of the cytokines on tumor cells can be detected under different times and strengths of light control. Therefore, cytokine releasing and other immune cell recruiting around the tumor cells can be realized in a human-controlled manner, growth andproliferation of tumor cells can be influenced, and the aim of changing the growing microenvironment of the tumor cells can be achieved finally.
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Description

technical field

[0001] The invention relates to the field of cancer treatment medicines, in particular to the application of light-regulated neutrophils in medicines for treating cancer. Background technique

[0002] As we all know, malignant tumors have become the leading cause of death in the world. According to statistics, about 8.8 million people died of cancer in 2015. The main causes of death include lung cancer, liver cancer, colon cancer, gastric cancer and breast cancer. There is a trend of rejuvenation. Traditional chemotherapy, radiotherapy and other methods cannot significantly improve the survival rate of cancer patients, especially for advanced patients. The emerging T cell chimeric antigen receptor (CAR-T) therapy, although in malignant B cell tumors, acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), etc. Significant progress has been made in blood-related malignancies, but there are still many problems: su...

Claims

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