Application of IL-17 in improving mesenchymal stem cell immunity inhibition function

An immunosuppressive, stem cell technology, applied in the field of biomedicine
CN105079792AInactive Publication Date: 2015-11-25SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
Publication Date
2015-11-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

Provided are uses of IL-17 in enhancing an immune-suppression function of mesenchymal stem cells. In particular, the present invention provides uses of an interleukin-17, a derivative of interleukin-17 or an agonist thereof for preparing a preparation or kit for enhancing an immune-suppression function of the mesenchymal stem cells; up-regulating the expression of imunosuppressive factors in the mesenchymal stem cells; enhancing the stability of mRNAs of the immunosuppressive factors; reducing the expression level of RNA-binding protein AUF1; inhibiting the proliferation of T cells; and treating hepatitis or liver damage.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, in particular, the invention relates to the application of IL-17 in improving the immunosuppressive function of mesenchymal stem cells. Background technique

[0002] Mesenchymal stem cells (MSCs) are an important member of the stem cell family, derived from the mesoderm and ectoderm in the early stages of development, and belong to pluripotent stem cells. MSCs were originally found in the bone marrow because of their multi-directional differentiation potential, hematopoietic support and The promotion of stem cell engraftment, immune regulation and self-replication has attracted increasing attention. For example, mesenchymal stem cells can be differentiated into fat, bone, cartilage, muscle, tendon, ligament, nerve, liver, cardiac muscle, endothelial and other tissue cells under specific induction conditions in vivo or in vitro, after continuous subculture and cryopreservation It still has multi-direct...

Claims

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