Immunoadjuvant and its application in diffuse large b-cell lymphoma

An immune adjuvant and B cell technology, applied in the field of biomedicine, can solve the problems of lack of specificity, long-term drug toxicity, deficiency, etc., and achieve the effect of reducing the rate of cell proliferation
CN110812476BActive Publication Date: 2022-07-26FUJIAN MEDICAL UNIV UNION HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
FUJIAN MEDICAL UNIV UNION HOSPITAL
Publication Date
2022-07-26

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Abstract

The invention discloses an immune adjuvant for diffuse large B-cell lymphoma based on chemokine CCL20 and its application. It is used in large B-cell lymphoma. The immune adjuvant has a good anti-tumor effect in DLBCL in vitro and in vivo studies. Co-incubation with DLBCL cells can significantly reduce the cell proliferation rate of DLBCL. It acts as an immune adjuvant and inactivates tumors. After the mixed local injection of cells, the mice were generally in good condition, with no abnormal conditions such as convulsions, agitation, piloerection, and convulsions. There were no abnormalities such as redness, inflammation, ulceration, and induration at the local injection site, and non-tumor-bearing mice did not die. , suggesting that it can be used as an immune adjuvant for DLBCL, which can be used in clinical practice and has broad prospects.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, in particular to an immune adjuvant for diffuse large B-cell lymphoma based on chemokine CCL20 and its application. Background technique

[0002] As the fourth cancer therapy in addition to surgery, chemotherapy, and radiotherapy, immunotherapy has attracted widespread attention because it uses tumor-specific antigens to attack cancer cells, with the characteristics of invasiveness and few side effects. The current immunotherapy has high cost and weak immune effect, which limits its clinical application. Although the safety of new tumor vaccines has been significantly improved compared with traditional vaccines, the immune effects and immunogenicity are weaker. Therefore, the application of adjuvants to enhance and / or shape antigen-specific immune responses is particularly important in tumor immunotherapy.

[0003] Chemokines are a class of cytokines that induce directional migration of infl...

Claims

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