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Animal-derived biological artificial bladder

An artificial bladder, animal-derived technology, applied in the direction of bladder, human tubular structure device, etc., can solve the problems of inability to perceive the degree of bladder filling, inability to voluntarily contract urination, etc., and achieve good biocompatibility

Inactive Publication Date: 2020-03-03
NINGBO SHENGJIEKANG BIOTECH
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  • Abstract
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AI Technical Summary

Problems solved by technology

The most difficult problem is that this type of artificial bladder cannot sense the fullness of the bladder, nor can it voluntarily contract to urinate

Method used

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Embodiment Construction

[0021] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be described in detail below with reference to the accompanying drawings and examples.

[0022] Such as figure 1 and figure 2 As shown, an animal-derived biological artificial bladder is a medical artificial bladder that can be implanted in situ, and is composed of an artificial ureter, an artificial bladder body and an artificial urethra. The artificial ureter It is a pipe-shaped structure with a diameter of 0.5-0.7cm. The artificial urethra is a pipe-shaped structure with a diameter of 0.7-1.0cm. The artificial bladder body is an ellipsoidal structure with a capacity of 200-300ml. The artificial ureter, artificial urethra and artificial bladder body are integrally formed . The animal-derived biological artificial bladder is made by chemically modifying the animal bladder to remove antigen-carrying cell components in the original tissue and ...

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Abstract

The invention belongs to the field of medical artificial organs, and specifically relates to an animal-derived biological artificial bladder. The animal-derived biological artificial bladder is a medical artificial bladder that can be implanted in situ and consists of an artificial ureter, an artificial bladder body and an artificial urethra. The animal-derived biological artificial bladder is prepared by removing antigen-carrying cell components from original tissues after chemical modification of the animal bladder and retaining a framework for tissue regeneration. The animal-derived biological artificial bladder has better biocompatibility, and also has the same or similar structure as the extracellular matrix to perform cell adhesion, proliferation and differentiation. Thereby, the common problems such as infection, body rejection reaction, urinary calculus, renal function deterioration and the like that are brought to patients after total cystectomy are solved. In addition, the artificial bladder can sense the filling degree of the bladder, thus autonomously contracting and urinating without the aid of other external power devices.

Description

technical field [0001] The invention belongs to the field of medical artificial organs, and in particular relates to an animal-derived biological artificial bladder, which is suitable for patients with urethral diversion or bladder reconstruction. Background technique [0002] In recent years, with the increase in the incidence of bladder cancer, bladder cancer has become the most common malignant tumor of the genitourinary system, and it is also one of the ten most common tumors in the whole body. The current treatment for patients with advanced bladder cancer is usually total cystectomy and urinary diversion. Commonly used clinical methods are ureterocutaneous ostomy and self-intestinal bladder replacement surgery. The former is prone to bacterial infection at the stoma and requires an external urine collection device, which brings serious psychological and social troubles to patients; the latter It not only destroys the normal structure and function of the patient's own ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/04
CPCA61F2/042
Inventor 王宽陈智敏
Owner NINGBO SHENGJIEKANG BIOTECH
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