Method for rapid calibration of Raman spectrometer using acetaminophen

Abstract

The method of the present invention using acetaminophen to quickly calibrate the Raman spectrometer comprises: using a Raman spectrometer to collect the spectrum of the acetaminophen standard substance, collecting and obtaining n characteristic peak spectral peak positions; obtaining each characteristic peak spectral peak position difference ΔX n =X n -Y n , to calculate the average error ΔX 平均 =(ΔX 1 +ΔX 2 +ΔX 3 +...,ΔX n ) / n; Calculate the difference between each two consecutive measurement characteristic peak spectral peak positions L (n‑1)n =X n -X n‑1 , get the interval between two characteristic peak spectral peak positions; do difference calculation S for every two consecutive standard spectral peak positions (n‑1)n =Y n -Y n‑1 Get the interval between two standard spectral peaks; calculate the average shift coefficient A 平均 , when ΔX 平均 ≠0, modify the Raman spectrum measurement results, Z n修正后 =A 平均 *Z n +ΔX 平均 .

Description

technical field [0001] The invention relates to rapid calibration of a Raman spectrometer at 200-3400 wavenumbers by using acetaminophen standard substance, and realizes calibrating the spectrum of the Raman spectrometer by collecting paracetamol spectral data. Background technique [0002] The Raman spectrometer is an instrument that receives the Raman scattering spectrum. Raman scattering is an inherent characteristic of the molecules that make up the substance. Therefore, the analysis of the molecular structure of the substance can be realized by reading the Raman scattering spectrum of a certain substance. For this, the spectrometer cone The ability to accurately identify each characteristic peak in the spectrum of a substance is particularly important. Therefore, it is obviously necessary to quickly calibrate the spectrum of the Raman spectrometer before use. [0003] At present, there are two commonly used spectral calibration methods for Raman spectrometers; one is to...

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Problems solved by technology

[0004] Using the stable properties of single crystal silicon in a fixed form in nature, the obtained Raman spectrum is used to calibrate the Raman spectrometer. The advantage is that it is fast and simple. The disadvantage is that single crystal silicon only has a characteristic peak at 520cm-1, which cannot be realized at a distance of 520cm The spectrum at -1 is accurately calibrated, so the ability to correct the deviation of the Raman spectrum in the long-wavelength range is weak. The second method uses the natural frequency and fixed wavelength of the atomic spectral line. The advantage is that it can correct the overall long-spectrum For calibration, the disadvantage is that you need to carry a low-voltage atomic spectrum lamp, which is not conducive to the rapid on-site calibration of miniaturized instruments and portable instruments

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