31 results about "P-acetaminophenol" patented technology

Disclosed is a process for preparing 5-aminosalicylic acid by gas phase catalytic carboxylation, characterized in that carbon dioxide is introduced into a system of p-acetaminophenol and a basic compound at a temperature of 150° C.˜220° C. and a pressure of 0.5˜5.0 MPa in the presence of a catalyst, so as to carry out a gas phase catalytic carboxylation reaction to form a 5-aminosalicylate, and the crude product 5-aminosalicylate is separated, and then acidified to prepare 5-aminosalicylic acid (5-ASA). Since the gas phase catalytic reaction replaces a solid phase thermo-chemical reaction, the reaction is significantly improved in terms of the process flow, reaction conditions, product quality and energy consumption. In addition, the reaction has a short reaction time, good selectivity, high yield and no formation of wastes during the reaction, and is suitable for industrial production.

The invention relates to a regeneration method of inactivated activated carbon in a refining stage of acetaminophen. The method comprises an alcohol-alkali desorption stage, a water scrubbing stage, an acid pickling stage and a drying and activating stage. The method has the characteristics of low regeneration cost, simple operation, high regeneration rate, and high economic benefits; almost no carbon is loss in the regeneration process and mechanical property of the activated carbon is not damaged in the regeneration process; the solvent can be recycled for many times and causes no secondarypollution; and the regenerated activated carbon can adsorb 250-285mg / g of methylene blue, and meets the process requirement of the refining and impurity removal stage of acetaminophen on the activatedcarbon.

The invention provides a preparation technique of p-acetaminophenoxide; the technique includes the following steps: adding phenol, oxammonium hydrochloride, acetic acid and polyphosphate with mass ratio of 1 : 0.85 : 3.0 : 8.5 to 1 : 0.96 : 4.1 : 9.6 into a reactor and sealing the reactor; carrying out reflux reaction for 3.0 to 5.2h under normal pressure and constant temperature in an oil bath of 75 to 85 DEG C; cooling to the temperature of 20 to 30 DEG C; adding ice water of 10 to 15 times of the volume of the mixed matters into the reactor and adjusting pH to 3.5 to 4.5 by using ammonia; adding nitrogen into the reactor to replace air; adding sodium bisulfite of 1 to 2 times of the weight of phenol and then sealing the reactor, continuously carrying out reaction for 5.0 to 7.2h under the normal pressure and constant temperature in the oil bath of 110 to 132 DEG C, cooling, decompressing and vaporizing the solvent water, then using acetone to wash so as to filter out ammonium phosphate salt, combing the filtrate, vaporizing and recycling the acetone to obtain the crude product, using water to re-crystallize to obtain the white crystal of the p-acetaminophenoxide. The preparation technique of the invention takes the phenol, glacial acetic acid and the oxammonium hydrochloride as the raw materials, takes the polyphosphate as a catalyst, adopts one pot method to prepare the p-acetaminophenoxide and has the advantages of simple technique, mild reaction conditions, low manufacture cost and being environment friendly.

A copper oxide / carbon nanotube / carbon nitride electrochemical sensor for detecting acetaminophen, a preparation method therefor and an application thereof. The method comprises: mixing carboxylated carbon nanotubes, carbon nitride, and water uniformly, and performing sonication; then adding copper acetate, mixing uniformly, and performing sonication; and drying after the sonication, and then calcining in an inert gas atmosphere to obtain a copper oxide / carbon nanotube / carbon nitride composite material. A CuO / CNT / g-C3N4 composite modified electrode is prepared and used as an electrochemical sensor for detecting acetaminophen. The electrochemical result shows that the composite material has a good detection effect on acetaminophen.

The invention provides a method for constructing a metal-organic framework-based specific modified electrode, which is to ultrasonically disperse an aminated metal-organic framework and reduced graphene oxide in N,N-dimethylformamide, and make the dispersion The modified electrode rGO‑NH was prepared by drop-coating on the surface of the polished glassy carbon electrode 2 -Cu 3 (btc) 2 / GCE; with rGO‑NH 2 -Cu 3 (btc) 2 / GCE modified electrode is the working electrode to form a three-electrode system; insert HAuCl 4 H 2 SO 4 In the solution, the gold nanoparticles were deposited on the electrode surface by the potentiostatic deposition method, and the specifically modified electrode Au / rGO‑NH 2 -Cu 3 (btc) 2 / GCE. The modified electrode can completely separate the oxidation peaks of acetaminophen and para-aminophenol, and realize the simultaneous detection of the two; moreover, the detection method is fast and simple, and has good anti-interference and stability.