Device and method for optical detection and sorting of chiral particles

Abstract

The invention discloses a device and method for optical detection and sorting of chiral particles. The device is composed of a laser, a non-polarization beam splitting prism, a reflector, a vector light field generation system, a computer and a high numerical aperture objective lens; the method controls the vector through the computer. The light field generation system cuts the laser light emitted by the laser into a vector light field with a specific spatial distribution, and uses a high numerical aperture objective lens to focus it, and generates a transverse spin transverse optical needle focal field in the focal field area of ​​the objective lens. When a chiral particle interacts with the focal field of the transverse spin transverse optical needle, the achiral gradient force acting on the particle is suppressed by the focal field of the optical needle, and the particles with different chirality will be dissipated under the action of the chiral gradient force It is captured at different positions in the focal field of the optical needle, and rotates at the captured position with different frequencies. The invention can not only realize the detection of molecular chirality, but also can sort chiral particles without damage, and has broad application prospects in a series of fields related to chiral optics.

Description

technical field [0001] The invention relates to the field of nano optics technology, in particular to a device and technology for optical detection and sorting of chiral nanoparticles. Background technique [0002] Chirality refers to the geometric property that a substance cannot coincide with its mirror image through translation or rotation. Chirality exists widely in nature. Nucleic acids and proteins, which are important components of living organisms, are composed of chiral sugars and chiral amino acids. Most biological macromolecules such as polysaccharides, enzymes, nucleic acids, and receptors also have chirality. Two substances with opposite chiralities are called enantiomers and have opposite geometric configurations. Although the chemical molecules of the two substances that make up the enantiomers are the same, substances with different configurations often have different chemical properties and will produce different chemical effects. Therefore, the detection ...

AI Technical Summary

Problems solved by technology

However, as the particle size decreases, the chiral force will gradually be suppressed by the achiral gradient force, so the chiral detection of nanoscale particles still remains a challenge.

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