Dental mineralization and bleaching double-functional paste, preparation method and application

A dual-function, paste technology, applied in the field of tooth mineralization and bleaching dual-function paste preparation, achieves the effects of good mineralization activity, overcoming demineralization side effects, and reducing side effects

Active Publication Date: 2022-04-19
ANHUI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the stability of hydrogen peroxide and the preparation of calcium phosphate salts with high mineralization activity are two problems that must be solved

Method used

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  • Dental mineralization and bleaching double-functional paste, preparation method and application
  • Dental mineralization and bleaching double-functional paste, preparation method and application
  • Dental mineralization and bleaching double-functional paste, preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The paste preparation process of the present embodiment is as follows:

[0036] (1) 0.45mol of strontium chloride and 200g of polyethylene glycol are successively added to 0.6mol of phosphoric acid solution under agitation to dissolve them completely; In the solution of phosphate radical, the organic-inorganic compound mixed paste containing strontium calcium phosphate salt is obtained;

[0037] (2) transfer the organic-inorganic compound mixed paste containing strontium calcium phosphate salt obtained above to ball milling in an all-round planetary ball mill, and ball mill for 24 hours at a rotating speed of 250 rpm;

[0038] (3) gradually add phosphoric acid with a volume concentration of 85% in the mixture after ball milling, so that the pH value of the final mixed paste is in the range between 3.5 and 4.5; The pH value is between 3.5 and 4.5;

[0039] (4) Transfer the obtained paste to a constant temperature drying oven for normal pressure drying (60° C.) until it b...

Embodiment 2

[0043] The paste preparation process of the present embodiment is as follows:

[0044] (1) Add 0.2mol of sodium fluoride and 200g of polyacrylic acid to 0.6mol of phosphoric acid solution in sequence under stirring to dissolve them completely; then gradually add 1mol of calcium oxide to the above-mentioned phosphate-containing In the solution, an organic-inorganic compound mixed paste containing calcium fluorine phosphate is obtained;

[0045] (2) transfer the obtained organic-inorganic compound mixed paste containing fluorine-containing calcium phosphate to an omnidirectional planetary ball mill for ball milling for 24 hours at a speed of 250 rpm;

[0046] (3) Gradually add phosphoric acid with a volume concentration of 85% to the mixture after ball milling, so that the pH value of the final mixed paste is in the range between 3.5 and 4.5; then, continue ball milling for 8 hours under the same conditions, and determine the pH value of the mixed paste again Between 3.5 and 4....

Embodiment 3

[0051] The paste preparation process of the present embodiment is as follows:

[0052] (1) Add 0.2mol of sodium fluoride and 200g of polyvinylpyrrolidone into distilled water successively under stirring conditions to dissolve them completely; then gradually add 0.2mol of hydroxyapatite powder into the above solution under stirring conditions , to obtain an organic-inorganic compound mixed paste containing fluorine-containing calcium phosphate;

[0053] (2) transfer the obtained organic-inorganic compound mixed paste containing fluorine-containing calcium phosphate to an omnidirectional planetary ball mill for ball milling for 24 hours at a speed of 250 rpm;

[0054] (3) Add volume concentration 85% phosphoric acid gradually in the mixture after ball milling, make the pH value of the final mixed paste range between 3.5~4.5; Then continue ball milling for 8 hours under the same conditions, again determine the pH value of the mixed paste at Between 3.5 and 4.5;

[0055] (4) Tra...

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Abstract

The invention discloses a double-functional tooth mineralization and bleaching paste, a preparation method and an application thereof. The tooth bleaching preparation of the invention contains not only peroxide bleaching ingredients, but also mineralization ingredients of calcium phosphate salt, which can be used in bleaching teeth. At the same time, it induces the mineralization of teeth. The preparation of the invention can overcome the demineralization side effects of tooth bleaching preparations on the current market by inducing the mineralization of the tooth surface. The preparation of the present invention contains strontium compound and induces mineralization to seal dentin tubules, which can reduce the side effect of dentin hypersensitivity caused by bleaching. The preparation of the invention has good mineralization activity, so it can be used for the remineralization treatment of teeth. The preparation of the invention can induce the mineralization of teeth, seal the dentine tubules, and can be used for the treatment of dentine hypersensitivity.

Description

technical field [0001] The invention relates to a tooth bleaching and remineralization treatment medicine, in particular to a tooth mineralization and bleaching dual-function paste, a preparation method and application. Background technique [0002] With the continuous improvement of living standards, people's requirements for beauty are getting higher and higher. Teeth are an important part of the beauty of the face, and more and more attention has been paid to the beauty of its color and shape. Studies have shown that an "attractive smile" can improve people's self-confidence and role adaptability, and "white and bright" teeth are considered to be the most important component of an attractive smile. The change of tooth color will affect the patient's aesthetics and psychology, which is not conducive to the patient's social and work. Many sources report that adults are dissatisfied with the color of their teeth, thinking that it affects the appearance, eager to change the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/06A61K33/42A61K33/14A61K33/16A61K33/40A61K9/06A61K47/10A61K47/32A61P1/02A61K31/17
CPCA61K33/06A61K33/42A61K33/14A61K33/16A61K33/40A61K31/17A61K9/06A61K47/10A61K47/32A61P1/02A61K2300/00
Inventor 李柏霖李全利曹颖郑顺丽方泽辉邵辉吴乐平周庆丽王盛瑞
Owner ANHUI MEDICAL UNIV
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