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Probe for efficiently detecting mercury ions and preparation method and application thereof

A mercury ion and fluorescent probe technology, applied in the field of fluorescent probes, can solve problems such as inability to monitor mercury ions in situ, real-time, and online, poor water solubility, poor selectivity, etc., and achieve convenient qualitative analysis, high selectivity, and responsiveness. fast effect

Active Publication Date: 2020-03-31
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, the reported methods for detecting mercury ions include spectrophotometric colorimetry, high performance liquid chromatography, chemiluminescence analysis, and fluorescent probe analysis, among which fluorescent probes are highly selective, ultra-sensitive, and synthetic The unique advantages such as simplicity have become the focus of researchers. The reported fluorescent probe analysis methods still have certain defects, including low sensitivity, poor selectivity, poor water solubility, complex synthesis, etc., and cannot achieve in situ, real-time, online. Requirements for monitoring mercury ions

Method used

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  • Probe for efficiently detecting mercury ions and preparation method and application thereof
  • Probe for efficiently detecting mercury ions and preparation method and application thereof
  • Probe for efficiently detecting mercury ions and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: Synthesis of step a product (VII)

[0044] The reaction route is as follows:

[0045]

[0046] 3865 mg (20.0 mmol) of 4-(diethylamino) salicylaldehyde, 3383.64 mg (26 mmol) of ethyl acetoacetate and catalyst piperazine were added to absolute ethanol, reacted at 80°C for 12 h, and the crude product was separated by column chromatography to obtain The pure product was 3734 mg, and the yield was 73%.

Embodiment 2

[0047] Example 2: Synthesis of step b product (VIII)

[0048] The reaction route is as follows:

[0049]

[0050] 3630.2 mg (14 mmol) of the compound of formula (VII), 2481.3 mg (14 mmol) of 4-(dimethylamino)-2,3-dimethylbenzaldehyde and piperazine were dissolved in ethanol, heated to 80°C and refluxed for 12 h . The product was separated by column chromatography to obtain 3225 mg of pure product with a yield of 59%.

Embodiment 3

[0051] Example 3: Synthesis of step c product (II)

[0052] The reaction route is as follows:

[0053]

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PUM

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Abstract

The invention relates to a probe for efficiently detecting mercury ions and a preparation method and application thereof. Specifically, the probe provided by the invention is a fluorescent probe basedon coumarin compounds as fluorophores and mercaptan as a recognition receptor, can realize high-selectivity and ultra-sensitive analysis of mercury ions, and can determine the concentration of mercury ions in a sample. The probe can realize at least one of the following technical effects: high selectivity, strong anti-interference capability, quick response, convenient qualitative analysis, strong anti-interference capability, high sensitivity and wide detection range.

Description

technical field [0001] The invention belongs to the field of fluorescent probes, and in particular relates to coumarin compounds as fluorophores and thiols as fluorescent probes for recognizing receptors, which can achieve high selectivity for mercury ions and ultra-sensitive analysis, or can measure mercury ions in samples. The present invention also provides a method for preparing the fluorescent probe. Background technique [0002] Mercury, as a metal element with serious physiological toxicity, has attracted more and more attention due to the release of a large amount of mercury into the environment due to gold mining, petroleum refining and fossil fuels. Even at very low concentrations, mercury can still accumulate in the human body through the food chain, damage enzymes and proteins in the body, and cause various diseases, such as: brain damage, kidney damage, behavioral imbalance and cognitive impairment Wait. Mercury poisoning can have extremely bad effects on soci...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/16C09K11/06G01N21/64
CPCC07D311/16C09K11/06G01N21/6428G01N21/643C09K2211/1088C09K2211/1007
Inventor 虞亚敏柳彩云高娜朱宝存
Owner UNIV OF JINAN
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