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Enhanced photoacoustic/photo-thermal difunctional nanoprobe

A nano-probe, dual-function technology, applied in the field of nano-probes, can solve problems such as tissue thermal damage and treatment failure, and achieve the effects of improving stability, high-efficiency photothermal therapy, and improving photoacoustic/photothermal performance

Inactive Publication Date: 2020-04-14
HEBEI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, excessively high-energy excitation light will not only cause non-specific "thermal damage" to the tissue, but also cause other complications and lead to treatment failure, which poses a serious challenge to the application of light-responsive nanoprobes in the visualization of tumor diagnosis and treatment.

Method used

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  • Enhanced photoacoustic/photo-thermal difunctional nanoprobe
  • Enhanced photoacoustic/photo-thermal difunctional nanoprobe
  • Enhanced photoacoustic/photo-thermal difunctional nanoprobe

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Prepare 100 mL of mixed solution of CTAB and CTAC with concentrations of 50 mM and 80 mM respectively, add 10 mL of chloroauric acid with a concentration of 20 mM and silver nitrate with a concentration of 8 mM, add hydrochloric acid to make the pH value 5, and then add 5 mL of ascorbic acid with a concentration of 7.5 mM and 5 mL of catechol at a concentration of 120 mM. Stand still in a water bath device at 32 degrees Celsius for 6 hours, centrifuge the product, wash it with water, and redisperse it in 50 mL of water to obtain a gold nano-bipyramidal solution.

[0022] Take 10 mL of the above-prepared gold nano-bipyramid solution, add ammonia water to make the pH value 9, then add 1 mL of dopamine hydrochloride solution with a concentration of 45 mM, continue stirring at room temperature for 2.5 hours, centrifuge the resulting product, wash it with water, and redisperse it in 10mL of water, the gray-black AuNBPs@PDA solution was obtained.

[0023] Its morphology and ...

Embodiment 2

[0025] Prepare 100mL of CTAB and CTAC mixed solutions with concentrations of 20mM and 120mM respectively, add 10mL of chloroauric acid with a concentration of 50mM and silver nitrate with a concentration of 10mM, add hydrochloric acid to make the pH value 4, then add 5mL of ascorbic acid with a concentration of 9mM and 5 mL of catechol at a concentration of 120 mM. After standing in a water bath at 38 degrees Celsius for 9 hours, the product was centrifuged, washed with water, and redispersed in 50 mL of water to obtain a gold nanobiconic solution.

[0026] Take 10 mL of the above-prepared gold nano-bipyramid solution, add ammonia water to make the pH value 10, then add 1 mL of dopamine hydrochloride solution with a concentration of 80 mM, continue stirring at room temperature for 4 hours, centrifuge the resulting product, wash it with water, and redisperse it in 10mL of water, the gray-black AuNBPs@PDA solution was obtained.

[0027] The prepared gold nanobipyramids and AuNB...

Embodiment 3

[0029] The preparation concentration is respectively 100mL of CTAB and CTAC mixed solutions of 50mM and 100mM, adding 10mL concentration of 15mM chloroauric acid and silver nitrate of concentration 5mM, adding hydrochloric acid to make the pH value 5, then adding 5mL concentration of 6mM ascorbic acid and 5 mL of catechol at a concentration of 100 mM. After standing in a water bath at 35 degrees Celsius for 6 hours, the product was centrifuged, washed with water, and redispersed in 50 mL of water to obtain a gold nanobiconic solution.

[0030] Take 10 mL of the above-prepared gold nano-bipyramid solution, add ammonia water to make the pH value 9, then add 1 mL of dopamine hydrochloride solution with a concentration of 60 mM, continue stirring at room temperature for 4 hours, centrifuge the resulting product, wash it with water, and redisperse it in 10mL of water, the gray-black AuNBPs@PDA solution was obtained.

[0031] The prepared gold nanobicones and AuNBPs@PDA were formul...

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Abstract

The invention discloses a nanoprobe with enhanced photoacoustic / photo-thermal dual functions. The probe is a gold nano bipyramid wrapped by polydopamine. The preparation method comprises the steps ofa) adding chloroauric acid and silver nitrate into a CTAB and CTAC mixed solution, and adjusting the pH value to 4 to 6; adding an ascorbic acid solution and catechol, and standing at 25 to 40 DEG C for 1 to 10 hours; centrifugally washing with water and then re-dispersing in water to obtain gold nano bipyramids; and b) taking the gold nano bipyramid solution, adjusting the pH value to 8 to 11, then adding dopamine hydrochloride, carrying out a stirring reaction at room temperature for 1 to 4h, then carrying out centrifugal water washing, and re-dispersing in water to obtain the polydopamine-coated gold nano bipyramid solution. According to the nanoprobe disclosed by the invention, due to coating of polydopamine, the stability of gold nano bipyramids is improved, and the photoacoustic / photo-thermal properties of the gold nano bipyramids are improved. In tumor diagnosis and treatment, the low-concentration nanoprobe is used, and low-dose illumination is applied at the same time, so thathigh-resolution photoacoustic imaging diagnosis and efficient photo-thermal therapy can be obtained, and the nanoprobe has the characteristics of safety and high efficiency.

Description

technical field [0001] The invention relates to a nanoprobe, in particular to a nanoprobe with enhanced photoacoustic / photothermal dual functions. Background technique [0002] The development and progress of molecular imaging and molecular probe technology have important applications in the precise diagnosis, treatment and prognosis assessment of major diseases such as tumors. In particular, light-responsive nanoprobes have the advantages of no X-ray radiation, high resolution, strong tissue penetration, and less trauma, and show potential application prospects in the visualization of tumor diagnosis and treatment. At present, nanoprobe materials used for tumor photoacoustic imaging and phototherapy mainly include gold nanomaterials of different shapes (nanorods, nanostars, and nanocones, etc.), carbon-based / copper-based inorganic nanomaterials, and organic materials. Due to the limited light conversion efficiency of the material, it is usually necessary to increase the li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K41/00A61K49/22A61K47/34A61P35/00B82Y5/00B22F1/00B22F9/24B82Y40/00
CPCA61K9/5146A61K41/0052A61K49/225A61P35/00B22F9/24B82Y40/00B82Y5/00B22F1/0553B22F1/07B22F1/054
Inventor 曾乐勇吴頔
Owner HEBEI UNIVERSITY
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