Application of water extract of gomphrena globose to preparation of drugs used for treating acute liver injury of mice

Abstract

The invention relates to application of the water extract of gomphrena globose to preparation of drugs used for treating acute liver injury of mice, belonging to the field of medicines. The water extract of gomphrena globosa is crude extract powder obtained by soaking gomphrena globosa powder in purified water for 24 hours, repeating soaking three times, and then conducting concentrating and drying. The water extract of gomphrena globosa is proved to be capable of obviously improving the acute liver injury induced by acetaminophen (APAPAP) stimulation for the first time through the results ofpharmacological experiment. The results of animal experiments show that the water extract of gomphrena globosa significantly reduces the levels of AST and ALT in the serum of mice with acute liver injury and the level of MPO in liver tissues, and obviously reduces the inflammatory cell infiltration of the liver and alleviates the central venous congestion of the liver. The water extract of gomphrena globosa disclosed by the invention is exact in curative effect on acute liver injury, remarkable in effect and low in side effect, is of important significance to the development of new drugs, andhas wide medical application prospect.

Description

technical field [0001] The invention relates to the application of a thousand-day red water extract in the preparation of medicines for treating acute liver injury in mice, belonging to the field of medicine. Background technique [0002] The liver is one of the most important organs in humans and animals. It performs two important functions of metabolism and detoxification. As the most important detoxification organ, the liver is an important target of many drugs and exogenous chemicals. Liver injury is the result of various liver diseases, and it is the initiating link and common path for the occurrence, development and eventual hepatic failure of many serious liver diseases, among which chemical liver injury, immune liver injury and physical liver injury Various liver injuries such as liver disease are serious frequently-occurring common diseases in my country at present. The pathogenesis of liver injury is very complex, which is the result of multi-factors, multi-levels...

AI Technical Summary

Problems solved by technology

Therefore, when livestock and poultry are infected by germs, they have to increase the therapeutic dose of antibiotics, even after increasing the dose, they cannot achieve a good therapeutic effect.

On the one hand, the use of large doses of antibiotics can cause various toxic effects in animals, especially liver toxicity

On the other hand, the excessive use of these chemicals will increase drug residues in food, cause food safety problems, and threaten human health

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