Application of water extract of gomphrena globose to preparation of drugs used for treating acute liver injury of mice

A technology of acute liver injury and water extract, applied in the field of medicine, can solve the problems of ineffective treatment, increasing the therapeutic dose of antibiotics, increasing drug residues, etc.

Inactive Publication Date: 2020-04-24
JILIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, when livestock and poultry are infected by germs, they have to increase the therapeutic dose of antibiotics, even after increasing the dose, they cannot achieve a good therapeutic effect.
On the one hand, the use of large do

Method used

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  • Application of water extract of gomphrena globose to preparation of drugs used for treating acute liver injury of mice
  • Application of water extract of gomphrena globose to preparation of drugs used for treating acute liver injury of mice
  • Application of water extract of gomphrena globose to preparation of drugs used for treating acute liver injury of mice

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Embodiment Construction

[0013] Crude Extraction of Water Extract of Qianrihong

[0014] Grind amaranth into powder, weigh 30g of amaranth powder, place it in filter paper, soak in 300mL of pure water for 24 hours, collect the filtrate, and repeat soaking 3 times. Combine the filtrates from three times and concentrate to 30-50mL using a rotary evaporator. Store the filtrate in a 200mL beaker and dry it in a 60°C oven.

[0015] Mouse model of acute liver injury

[0016] Eighteen C57BL / 6 mice aged 6-8 weeks and weighing 18-22g were randomly divided into 6 groups, 3 mice in each group, respectively blank group, APAP (500mg / kg) model group, and Qianrihong water extract Drug control group (300mg / kg), APAP+drug low concentration group (100mg / kg), APAP+drug high concentration group (300mg / kg). The method of intragastric administration was continued for one week, and the blank group and the APAP model group were given the same amount of normal saline. One week later, one hour after intragastric administrat...

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Abstract

The invention relates to application of the water extract of gomphrena globose to preparation of drugs used for treating acute liver injury of mice, belonging to the field of medicines. The water extract of gomphrena globosa is crude extract powder obtained by soaking gomphrena globosa powder in purified water for 24 hours, repeating soaking three times, and then conducting concentrating and drying. The water extract of gomphrena globosa is proved to be capable of obviously improving the acute liver injury induced by acetaminophen (APAPAP) stimulation for the first time through the results ofpharmacological experiment. The results of animal experiments show that the water extract of gomphrena globosa significantly reduces the levels of AST and ALT in the serum of mice with acute liver injury and the level of MPO in liver tissues, and obviously reduces the inflammatory cell infiltration of the liver and alleviates the central venous congestion of the liver. The water extract of gomphrena globosa disclosed by the invention is exact in curative effect on acute liver injury, remarkable in effect and low in side effect, is of important significance to the development of new drugs, andhas wide medical application prospect.

Description

technical field [0001] The invention relates to the application of a thousand-day red water extract in the preparation of medicines for treating acute liver injury in mice, belonging to the field of medicine. Background technique [0002] The liver is one of the most important organs in humans and animals. It performs two important functions of metabolism and detoxification. As the most important detoxification organ, the liver is an important target of many drugs and exogenous chemicals. Liver injury is the result of various liver diseases, and it is the initiating link and common path for the occurrence, development and eventual hepatic failure of many serious liver diseases, among which chemical liver injury, immune liver injury and physical liver injury Various liver injuries such as liver disease are serious frequently-occurring common diseases in my country at present. The pathogenesis of liver injury is very complex, which is the result of multi-factors, multi-levels...

Claims

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Application Information

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IPC IPC(8): A61K36/21A61P1/16
CPCA61K36/21A61P1/16
Inventor 冯海华覃海燕金美玉王建锋沈冰玉李铮王齐赵立磊
Owner JILIN UNIV
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