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Application of fructose diphosphate in preparation of medicament for treating affective disorders

A fructose diphosphate and affective disorder technology, applied in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as adverse reactions, anxiety disorders, and low diagnosis and treatment rates of epilepsy comorbidities. Achieve the effects of improving depression, anxiety and memory

Inactive Publication Date: 2020-05-08
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The survey of epileptic comorbid affective disorders shows that most neurologists mainly treat epileptic seizures, and the diagnosis and treatment rates of epileptic comorbidities are low.
At present, the main treatment of epilepsy is drug therapy, but there are certain adverse reactions when drugs control epileptic seizures.
Studies have found that many drugs for the treatment of epilepsy cannot effectively treat emotional disorders, and may even cause anxiety disorders and increase the risk of emotional disorders; some drugs for the treatment of emotional disorders can reduce the threshold of seizures or affect the metabolism of antiepileptic drugs, thereby increasing the risk of epilepsy. seizure risk

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1, the therapeutic effect of fructose diphosphate on the cognitive and emotional disorders of status epilepticus model rats with epilepsy

[0022] 1. Experimental method

[0023] Adult Wistar rats, weighing about 250 g, were obtained from Chengdu Dashuo Experimental Animal Co., Ltd.

[0024] Adult rats were intraperitoneally injected with Pilocarpine (Pilo, 30mg / kg) and Kainic acid (Kainicacid, 10mg / kg) to induce status epilepticus, and diazepam was given to terminate the status epilepticus after 40 minutes of status epilepticus. After the status epilepticus was terminated, the experimental animals were divided into two groups, ① FDP group (10 rats) was given FDP (1 g / kg) every day, ② control group (10 rats) was given the same amount of normal saline. Behavioral tests were performed at 2 months, 3 months, and 4 months after the termination of status epilepticus. Behavioral tests include water maze test, open field test, forced swim test, and fear test. The te...

Embodiment 2

[0045] Example 2, Therapeutic Effect of Fructose Diphosphate on Cognitive and Affective Disorders in Acute Epilepsy Rats

[0046] 1. Experimental method

[0047] Adult rats were injected intraperitoneally with pentylenetetrazol (50mg / kg) or myrzalide (2mg / kg) once a day to induce an acute epileptic seizure model. The experiment was divided into 4 groups (10 rats in each group). Groups ① and ③ were FDP groups, and groups ② and ④ were control groups; among them, group ① was given daily injections of FDP (1g / kg), ② group was given daily injection of the same amount of normal saline to the acute epileptic seizure model induced by pentylenetetrazol, ③ group was given FDP (1g / kg) by daily injection to the acute seizure model induced by masangolactone, ④ The group was injected with the same amount of normal saline daily for the model of acute epileptic seizures induced by mosan lactone. Water maze test, open field test, forced swimming test and fear test were performed on the 10th...

Embodiment 3

[0055] Example 3, Therapeutic Effect of Fructose Diphosphate on Cognitive and Affective Disorders in Chronic Epilepsy Model Rats with Epilepsy

[0056] 1. Experimental method

[0057] Adult rats were randomly divided into 4 groups (10 rats in each group). Groups ① and ③ were FDP groups, and groups ② and ④ were control groups; among them, group ① was injected with FDP (1g / kg) daily, and group ② was injected with FDP daily The same amount of normal saline, the group ③ was injected with FDP (1g / kg) every day, the group ④ was injected with the same amount of normal saline every day, and after 1 hour, the group ① was injected with pentetrazol (30mg / kg), and the group ② was injected with pentetrazol Nitrogen (30mg / kg), group ③ was injected with massanolactone (1.50mg / kg), and group ④ was injected with massanolactone (1.50mg / kg) to induce a chronic epileptic seizure model. Water maze test, open field test, forced swimming test and fear test were performed on the 10th and 20th day of...

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Abstract

The invention provides an application of fructose diphosphate in preparation of a medicine for treating affective disorders. Experimental results of the invention show that the fructose diphosphate can improve depression and anxiety states, and can effectively treat the affective disorders, especially has a significant therapeutic effect on epileptic comorbidity affective disorders caused by epilepsy. Therefore, the fructose diphosphate has very good application prospects in the preparation of the medicine for treating the affective disorders, especially the epileptic comorbidity affective disorders.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to the application of fructose diphosphate in the preparation of drugs for treating affective disorders, especially epileptic comorbid affective disorders. Background technique [0002] Epilepsy is defined as a chronic benign brain disorder characterized by a persistent susceptibility to seizures with corresponding neurobiological, cognitive, psychological, and social consequences. Some diseases tend to coexist with epilepsy in the same individual, and different diseases are difficult to distinguish between primary and secondary, and affect each other, which is called epilepsy comorbidity. Among them, the common comorbidities of epilepsy include cognitive impairment, affective disorder, migraine, schizophrenia, attention deficit hyperactivity disorder, sleep disorder, psychological disorder, mitochondrial encephalomyopathy, etc. The pathogenesis of epilepsy comorbidity is not ye...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7024A61P25/08A61P25/18A61P25/28A61P25/22A61P25/24
CPCA61K31/7024A61P25/08A61P25/18A61P25/22A61P25/24A61P25/28
Inventor 陈蕾邱湘苗
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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