A class of andrastone compound and its preparation method and application in the preparation of antiallergic drugs

A compound and anti-allergic technology, applied in andrastone compounds and its preparation, and the application field of preparing anti-allergic drugs, can solve problems such as adverse reactions and easy drug resistance, and achieve good application prospects

Active Publication Date: 2021-06-15
THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES +1
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this type of drug has a quick onset and obvious curative effect, it has certain adverse reactions and is prone to drug resistance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A class of andrastone compound and its preparation method and application in the preparation of antiallergic drugs
  • A class of andrastone compound and its preparation method and application in the preparation of antiallergic drugs
  • A class of andrastone compound and its preparation method and application in the preparation of antiallergic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Preparation of andrastone compounds

[0018] (1) Penicillium allii-sativi was cultured on a PDA plate at 25° C. for 3 days. The fresh mycelium was then inoculated into the culture medium containing 400 mL of PDB. After 24 hours, 10 mL of seed solution was inoculated into 1 L Erlenmeyer flasks (100 bottles), and each bottle had 80 g of oats and 120 mL of 3% seawater, and cultured statically at 28° C. for 30 days. The Penicillium allii-sativi is fermented and cultivated to obtain a fermented product;

[0019] The Penicillium allii-sativi is preserved in the China Marine Microorganism Culture Collection Management Center, and the preservation number is: MCCC 3A00580. For details, see the related literature "Andrastone A From the Deep-Sea-Derived FungusPenicillium allii-sativi Actsas an Inducer of Caspase and RXRa-Dependent Apoptosis" published in Frontiers in Chemistry, Front.Chem.2019, 7, 692.

[0020] (2) The fermented product obtained in step (1) was ex...

Embodiment 2

[0038] Example 2: Investigation of the Antiallergic Activity of Compounds 1-14 Prepared in Example 1

[0039] Rat Basophilic Leukemia-cell (RBL-cell) has a good allergic immune response in the diagnosis and immunotherapy of food allergy. The RBL-2H3 cell line has high viability and good uniformity, and can be used to establish cell models of allergic reactions. Therefore, the RBL-2H3 cell model is widely used in the anti-food allergy research of natural active ingredients, including degranulation, release of allergic mediators and their mechanism of action. The RBL-2H3 cell model mediated by immunoglobulin (IgE) was used to detect the degranulation efficiency of the cells after sensitization, and the inhibition rate of the compound samples on the degranulation efficiency of the cells was calculated to judge the anti-allergic activity of the samples.

[0040] The detailed steps are as follows:

[0041] 1) RBL-2H3 cells were recovered by trypsinization, 6×10 5 cells / mL, add 1...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a class of andrastone compounds derived from deep-sea fungi, a preparation method thereof and an application in the preparation of antiallergic drugs. The structures of the andrastone compounds 1-14 derived from deep-sea fungi are shown in formulas I-XIV respectively, and can be used for preparing antiallergic drugs.

Description

technical field [0001] The present invention relates to the technical field of antiallergic drugs, more specifically, the present invention relates to a class of andrastone compounds, their preparation methods and their application in the preparation of antiallergic drugs. Background technique [0002] Food allergy is a common allergic disease, which is produced by the cross-linking of allergen-specific IgE and FcεR I, causing effector cells to release allergic mediators, and severe cases will cause anaphylactic shock. According to statistics, about 5% of adults and 8% of infants worldwide are allergic to food. Food allergy diseases cannot be completely cured today, and the more common treatment is to use drugs to control them, such as the use of antihistamines, hormones and receptor antagonists, etc. are relatively common treatment methods. Although these drugs have quick onset and obvious curative effects, they have certain adverse reactions and are prone to drug resistan...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C07J1/00C07J71/00A61P37/08A61K31/58A61K31/585A61K31/566C12N1/14C12P33/00C12P33/20C12R1/80
CPCA61P37/08C07J1/0059C07J71/0005C12P33/00C12P33/20C12N1/145C12R2001/80
Inventor 杨献文谢春兰夏金梅何志辉
Owner THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap