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Anrastone compounds, preparation method thereof, and application of compounds in preparation of anti-allergic drugs

A compound and anti-allergic technology, applied in the preparation of anti-allergic drugs, andrastone compounds and their preparation fields, can solve problems such as adverse reactions and easy drug resistance

Active Publication Date: 2020-06-02
THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this type of drug has a quick onset and obvious curative effect, it has certain adverse reactions and is prone to drug resistance

Method used

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  • Anrastone compounds, preparation method thereof, and application of compounds in preparation of anti-allergic drugs
  • Anrastone compounds, preparation method thereof, and application of compounds in preparation of anti-allergic drugs
  • Anrastone compounds, preparation method thereof, and application of compounds in preparation of anti-allergic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Preparation of andrastone compounds

[0018] (1) Penicillium allii-sativi was cultured on a PDA plate at 25° C. for 3 days. The fresh mycelium was then inoculated into the culture medium containing 400 mL of PDB. After 24 hours, 10 mL of seed solution was inoculated into 1 L Erlenmeyer flasks (100 bottles), and each bottle had 80 g of oats and 120 mL of 3% seawater, and cultured statically at 28° C. for 30 days. The Penicillium allii-sativi is fermented and cultivated to obtain a fermented product;

[0019] The Penicillium allii-sativi is preserved in the China Marine Microorganism Culture Collection Management Center, and the preservation number is: MCCC 3A00580.

[0020] (2) The fermented product obtained in step (1) was extracted three times with ethyl acetate. The organic solvent was evaporated under reduced pressure to obtain an organic extract (200 g). These extracts were passed through a normal-phase column chromatography and eluted with petrole...

Embodiment 2

[0034] Example 2: Investigation of the Antiallergic Activity of Compounds 1-14 Prepared in Example 1

[0035] Rat Basophilic Leukemia-cell (RBL-cell) has a good allergic immune response in the diagnosis and immunotherapy of food allergy. The RBL-2H3 cell line has high viability and good uniformity, and can be used to establish cell models of allergic reactions. Therefore, the RBL-2H3 cell model is widely used in the anti-food allergy research of natural active ingredients, including degranulation, release of allergic mediators and their mechanism of action. The RBL-2H3 cell model mediated by immunoglobulin (IgE) was used to detect the degranulation efficiency of the cells after sensitization, and the inhibition rate of the compound samples on the degranulation efficiency of the cells was calculated to judge the anti-allergic activity of the samples.

[0036] The detailed steps are as follows:

[0037] 1) RBL-2H3 cells were recovered by trypsinization, 6×10 5 cells / mL, add 1...

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PUM

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Abstract

The invention discloses andrasone compounds derived from deep sea fungi, a preparation method thereof, and an application of the compounds in the preparation of anti-allergic drugs. The structures ofthe anrasone compounds 1-14 derived from the deep sea fungi are respectively represented by formulas I-XIV, and the anrasone compounds 1-14 can be used for preparing anti-allergic drugs.

Description

technical field [0001] The present invention relates to the technical field of antiallergic drugs, more specifically, the present invention relates to a class of andrastone compounds, their preparation methods and their application in the preparation of antiallergic drugs. Background technique [0002] Food allergy is a common allergic disease, which is produced by the cross-linking of allergen-specific IgE and FcεR I, causing effector cells to release allergic mediators, and severe cases will cause anaphylactic shock. According to statistics, about 5% of adults and 8% of infants worldwide are allergic to food. Food allergy diseases cannot be completely cured today, and the more common treatment is to use drugs to control them, such as the use of antihistamines, hormones and receptor antagonists, etc. are relatively common treatment methods. Although these drugs have quick onset and obvious curative effects, they have certain adverse reactions and are prone to drug resistan...

Claims

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Application Information

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IPC IPC(8): C07J1/00C07J71/00A61P37/08A61K31/58A61K31/585A61K31/566C12N1/14C12P33/00C12P33/20C12R1/80
CPCA61P37/08C07J1/0059C07J71/0005C12P33/00C12P33/20C12N1/145C12R2001/80
Inventor 杨献文谢春兰夏金梅何志辉
Owner THIRD INST OF OCEANOGRAPHY MINIST OF NATURAL RESOURCES
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