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Application of specific lectin combination in construction of test tool for identifying ultra-early liver cancer based on saliva glycoprotein sugar chain

A technology for early stage liver cancer and lectin, which can be used in measurement devices, instruments, scientific instruments, etc., and can solve problems such as abundance differences

Active Publication Date: 2020-07-07
深圳格道糖生物技术有限公司
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  • Application Information

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Problems solved by technology

And there is also a significant difference in the abundance of the same protein between serum and saliva

Method used

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  • Application of specific lectin combination in construction of test tool for identifying ultra-early liver cancer based on saliva glycoprotein sugar chain
  • Application of specific lectin combination in construction of test tool for identifying ultra-early liver cancer based on saliva glycoprotein sugar chain
  • Application of specific lectin combination in construction of test tool for identifying ultra-early liver cancer based on saliva glycoprotein sugar chain

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Experimental program
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Embodiment Construction

[0034] The previous PCA analysis based on lectin chip data found that there is an obvious overlapping area between patients with liver cirrhosis and liver cancer patients, and the patients with liver cirrhosis in the overlapping area are either considered to be patients with a high probability of cancer or have already been diagnosed with liver cancer. It is the early stage of malignant transformation, so it is defined as Ultra-Early Hepatic Carcinoma (UE-HCC) (such as figure 1 shown). The relevant verification experiments and analysis of the focus of this application are described in detail below, and the inventor's specific research and development process is not limited to this.

[0035] 1. Research methods:

[0036] 1.1. Collection and pretreatment of saliva samples

[0037]The saliva samples of HC patients and UE-HCC patients used in this experiment were strictly approved by Northwest University, Shaanxi Provincial People's Hospital and the Second Affiliated Hospital of...

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Abstract

The invention discloses an application of a specific lectin combination in construction of a test tool for identifying ultra-early liver cancer based on a saliva glycoprotein sugar chain, wherein thespecific lectin combination is selected from three kinds of lectin of LTL, STL and MAL-I; compared with a liver cirrhosis sample, an ultra-early liver cancer sample has the advantages that LTL and MAL-I are significantly up-regulated, and STL is significantly down-regulated. Besides, an accurate test model is constructed, and a user can calculate the following detection values according to a lectin test result; if the detection value is greater than or equal to 0.4931, it is indicated that the main body to which the saliva sample belongs is an ultra-early liver cancer patient (UE-HCC), otherwise, it is indicated that the main body to which the saliva sample belongs is a liver cirrhosis patient (HC).

Description

technical field [0001] The present invention relates to the application of a specific lectin combination in constructing relevant ultra-early liver cancer testing tools. Background technique [0002] Hepatic carcinoma (HCC) is a malignant tumor of the liver. Primary liver malignant tumors originate from the epithelial or mesenchymal tissues of the liver. Cirrhosis can progress to liver cancer if left untreated. Due to the insidious onset of liver cancer, no symptoms or no obvious symptoms in the early stage, and the rapid development of liver cancer, the diagnosis is that most patients have reached locally advanced or distant metastasis. Therefore, treatment is difficult and the prognosis is poor. my country is a high prevalence area of ​​chronic hepatitis, especially hepatitis B. About 120 million people carry hepatitis B (Hepatitis B, HB) virus for a long time, and there are about 30 million chronic hepatitis patients. About 300,000 chronic hepatitis patients develop liv...

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Application Information

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IPC IPC(8): G01N33/574G16H50/20
CPCG01N33/57488G01N33/57438G16H50/20
Inventor 李铮舒健
Owner 深圳格道糖生物技术有限公司
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