Use of Amuc1100 protein

A technology of protein and protein derivation, applied in the field of medicine

Active Publication Date: 2020-09-22
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Studies have found that it is significantly related to the effectiveness of PD-1 in treating cancer, diabetes, type 2 obesity and other metabolic and immune d

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] The rats were randomly divided into MA exposure group and saline control group for MA-induced CPP experiment. The experimental procedure mainly includes the adaptation period (the first day), pre-test (the second day, baseline), training (the third day to the twelfth day) and the test (the thirteenth day). In the acclimatization phase, the rats were put into the middle box of the CPP device and allowed to explore freely in the CPP device for 30 minutes. During the pre-test, the rats were put into the middle box of the CPP device and freely explored in the CPP device for 15 minutes. The side with the shorter stay time was the side with the drug. During the training phase, the MA exposure group was injected with methamphetamine (0.5%; 2mg / kg, 0.4ml / kg, intraperitoneal injection) on odd days, while the normal saline control group was injected with an equal volume of normal saline into the side of the concomitant drug. Even days in the training phase, Both groups were injec...

Embodiment 2

[0073] In order to explore the effects of addictive substances on AKK, we further compared the changes in AKK of rats in the normal saline control group and the susceptibility group to methamphetamine before and after the administration, and found that individuals with low sensitivity to methamphetamine rewards , That is, rats that did not form an obvious preference for methamphetamine rewards and related environmental cues, the relative abundance of AKK did not change significantly, while individuals who were sensitive to methamphetamine rewards and their related environmental cues had strong memory ability Compared with low-sensitivity individuals, the relative abundance of AKK increased significantly, see the results Figure 4 .

[0074] It can be seen that the relative abundance of AKK only increases significantly in individuals who are sensitive to the reward effects of psychoactive substances and have strong memory abilities in related environmental cues.

Embodiment 3

[0076] Rats were given the broad-spectrum antibiotics bacitracin 70mg / kg, neomycin 280mg / kg, vancomycin 28mg / kg, pimaricin 168ug / kg orally once a day, the control group rats were given the same amount of deionized water once a day, and the MA conditions were started after 7 days Sexual position preference training, the results show that compared with the control group, rats in the antibiotic group are significantly more sensitive to MA rewards, and the intestinal flora diversity of rats treated with broad-spectrum antibiotics is significantly reduced , While the relative abundance of AKK increased significantly. See the results Figure 5 .

[0077] It can be seen that the interference of antibiotics with the intestinal flora of MA addicted rats can increase the relative abundance of AKK and significantly increase the sensitivity to MA reward.

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Abstract

The invention relates to the technical field of medicine, in particular to a use of the Amuc1100 protein. The research shows that the Amuc1100 protein or a host expressing the Amuc1100 protein has theeffect of improving the emotion memory, including promoting the regression of the negative emotion memory and/or enhancing the positive emotion memory. The Amuc1100 protein can be applied to the preparation of drugs for addiction withdrawal, or can be applied to the preparation of drugs for treating at least one of anxiety disorder, obsessive-compulsive disorder, autism, dementia and schizophrenia.

Description

Technical field [0001] The present invention relates to the field of medical technology, in particular to the use of Amuc1100 protein. Background technique [0002] The enhancement of the ability of positive emotional memory and the ability of negative emotional memory to fade is essential for the adaptability of the body. The damage is post-traumatic stress disorder (PTSD), generalized anxiety disorder, depression, social phobia and spatial place phobia And other signs of emotional memory disorders. Studies believe that when a new positive emotional memory is formed to suppress the initial negative emotional memory, the fear response and depression will be alleviated. For example, after the conditioned fear response is established according to the principle of Pavlovian conditioning, if the subject is exposed to the previous conditioned stimulus again without the expected negative unconditioned stimulus, after repeated exposure, the previously established conditioned fear The ...

Claims

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Application Information

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IPC IPC(8): C07K14/195C12N15/70C12N1/21A61K38/16A61P25/18A61P25/20A61P25/22A61P25/28A61P25/30C12R1/19
CPCC07K14/195C12N15/70A61K38/164A61P25/18A61P25/20A61P25/22A61P25/28A61P25/30
Inventor 张晓洁陈体傅潇雅杨铖李云飞扬文杰
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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