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Application of fisetin and salt thereof to preparation of drugs resisting radiation damages

A fisetin and anti-radiation technology, which is applied in the field of medicine to achieve the effects of easy promotion and use, a wide range of applications, and reduced side effects

Inactive Publication Date: 2020-09-25
INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, there is no research report on the effects of fisetin compounds on anti-ionizing radiation damage drugs

Method used

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  • Application of fisetin and salt thereof to preparation of drugs resisting radiation damages
  • Application of fisetin and salt thereof to preparation of drugs resisting radiation damages
  • Application of fisetin and salt thereof to preparation of drugs resisting radiation damages

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A kind of application of fisetin and its salt in the preparation of anti-radiation damage medicine, the specific steps are as follows:

[0044] Five mice were taken, and the mice were irradiated with gamma rays, wherein the irradiation dose was 10Gy. The fisetin was dissolved in a mixed solvent composed of 60% Phosal 50PG, 30% PEG400 and 10% ethanol at a concentration of 500 mg / ml. 48h, 24h and 1h before the irradiation, the mice were given fisetin solution by intragastric administration according to 100 mg / kg fisetin. 24h and 48h after the irradiation, the drugs were administered once again, and the irradiation was continued for 3 days.

Embodiment 2

[0064] A kind of application of fisetin and its salt in the preparation of anti-radiation damage medicine, the specific steps are as follows:

[0065] 15 mice were irradiated locally on the right side of the chest with γ-rays for 4 months, and the irradiation dose was 17Gy. Four months after the mice were irradiated, fisetin was administered continuously for 10 days and empty for 9 days for 2 cycles. Wherein the dosage is fisetin 100mg / kg.

Embodiment 3

[0076] A kind of application of fisetin and its salt in the preparation of anti-radiation damage medicine, the specific steps are as follows:

[0077] 10 mice were irradiated with X-rays for 1 month, and the irradiation dose was 7.5Gy. 48 hours, 24 hours, 1 hour before irradiation, 24 hours after irradiation, and 48 hours after irradiation, the mice were administered once, for a total of 5 administrations. Wherein the dosage is fisetin 100mg / kg.

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PUM

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Abstract

The invention discloses an application of fisetin and a salt thereof to preparation of drugs resisting radiation damages, relates to the technical field of medicines and particularly discloses the fisetin which can be applied to multiple radioactive organ damages and DNA damages caused by ionizing radiation, such as X-rays and gamma-rays, and simultaneously can be applied to adjuvant drugs for radiotherapy for tumors. The fisetin and the salt thereof disclosed by the invention widely exist in the nature and have significant prevention and treatment effects on multiple radiation damages. Therefore, a new idea is provided for the application of the fisetin; a new raw material is provided for the drugs resisting the radiation damages; and the fisetin is applied to the drugs resisting the radiation damages, so that the production cost of the drugs can be reduced, market promotion is facilitated and the economic pressure of patients is alleviated.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of fisetin and its salts in the preparation of anti-radiation damage medicines. Background technique [0002] Radiation can be divided into non-ionizing radiation and ionizing radiation. Among them, the energy of ionizing radiation is stronger than that of non-ionizing radiation, which can cause greater damage to human health. Ionizing radiation includes natural ionizing radiation and artificial radiation, and natural ionizing radiation includes cosmic rays, earth-native radionuclides, decay products of radon in the air, and various naturally occurring radionuclides; artificial radiation includes medical X-rays, Radioactive dust from nuclear weapons tests, radioactive waste discharged by the nuclear industry, industrial gamma rays, 60Co rays, heavy ion radiation, radiation in tumor radiotherapy, etc. In recent years, with the deepening of human utilization of ...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P1/00A61P7/00A61P39/06
CPCA61K31/352A61P1/00A61P7/00A61P39/06
Inventor 李德冠董辉董银萍王梅芳张远洋吴静
Owner INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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