Application of small molecular compound to improvement of pathogenic bacteria clearing capacity of host and application to preparation of pathogenic bacteria infection resistant drugs

Abstract

The invention relates to the technical field of biology, in particular to application of a small molecular compound to improvement of the pathogenic bacteria clearing capacity of a host and application of the small molecular compound to preparation of pathogenic bacteria infection resistant drugs. According to the invention, a metabonomics technology is utilized, and metabolic changes of the serumof mice infected with pathogenic bacteria are analyzed, so that a small molecular compound capable of improving the pathogenic bacteria clearing capability and resistance capability of a host, reducing the content of pathogenic bacteria in the host, improving the survival rate and particularly improving the staphylococcus aureus / MRSA infection resistance capability of the host can be screened out. Directed at the application of the small molecule compound, and the effect of the small molecule compound is realized by taking metabolism to adjust the immunity of the host as an entry point for adjusting the immunity of a host to resist pathogenic bacteria infection, so that the risk of generating drug-resistant bacteria can be eliminated by the method. Besides, the small molecular compound can play a better role in protecting the host in the synergistic effect of antibiotics, is beneficial to shortening the service cycle of the antibiotics, and reduces the generation of drug-resistant bacteria as much as possible.

Description

Technical field [0001] The present invention relates to the field of biotechnology, in particular to the use of small molecule compounds for improving the host's ability to eliminate pathogenic bacteria and the use in the preparation of anti-pathogenic bacteria infection drugs. Background technique [0002] At present, all diseases against Staphylococcus aureus infection are treated with antibiotics, leading to the occurrence of resistant bacteria such as MRSA. Therefore, it has become embarrassing for antibiotics to treat drug-resistant bacterial infections. New antibiotic inventions cannot keep up with the speed of bacterial resistance. The shortcomings of using antibiotics to treat Staphylococcus aureus infections are that, on the one hand, antibiotic treatment produces drug-resistant bacteria very quickly, resulting in no antibiotics available for later treatment of drug-resistant bacteria; on the other hand, the screening cycle of new antibiotics is very long and the cost is ...

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the problems of using antibiotics to treat pathogenic bacteria infection, which will produce drug-resistant bacteria and the screening cycle of new antibiotics is long, etc., and uses metabolomics technology to screen anti-infection small molecules from the serum of infected mice to screen out the anti-infection small molecules that can improve the host The ability to clear and resist pathogenic bacteria, and the small molecule metabolites that reduce the content of pathogenic bacteria in the host, thereby providing a use of the screened small molecule compound for improving the host’s ability to clear pathogenic bacteria, and the screened small molecule Application of compound in preparation of anti-pathogen infection medicine

Images