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Application of timolol or salts thereof to preparation of medicine for preventing and/or treating plexiform angioma

A technology for timolol maleate and hemangioma, which is applied in the field of medicine to achieve the effects of less skin blemishes and less local itching

Pending Publication Date: 2020-10-16
BEIJING CHILDRENS HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of treatment, for high-risk infantile hemangiomas, the preferred treatment is oral propranolol, while for plexiform hemangiomas, the previous preferred treatment was surgical resection, but surgical resection for larger lesions has great limitations. limitation

Method used

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  • Application of timolol or salts thereof to preparation of medicine for preventing and/or treating plexiform angioma
  • Application of timolol or salts thereof to preparation of medicine for preventing and/or treating plexiform angioma
  • Application of timolol or salts thereof to preparation of medicine for preventing and/or treating plexiform angioma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A 5-year-old girl presented with a 4-year history of painful purpuric plaques on the right arm. Four years earlier, the patient's parents had discovered a red papule on the outer right upper arm after a mosquito bite. On physical examination, dark red papules on the right upper arm merged into annular plaques ( figure 1 A-C). Skin biopsy performed at initial evaluation revealed hyperplastic masses of vascular endothelial cells in a typical "cannonball" distribution of scattered oval dermal lobules in the middle dermis, surrounded by fissures ( figure 1 D). Immunohistochemistry showed positive staining of endothelial cells in lobules for CD31 and VEGF ( figure 1 E, F), but negative for GLUT-1. No Kasabach-Merritt phenomenon was found in the platelet examination of the child. The final diagnosis was TA.

[0033] Based on the results of adenosine triphosphate-tumor chemosensitivity assay, 0.5% timolol maleate wet compress (using 0.5% (g / mL) timolol maleate (0.5% T...

Embodiment 2

[0036] A 2-year-old boy presented with four painful dark red nodules on his neck from birth. Afterwards, the nodules continued to proliferate and coalesce into violet-colored plaques with annular margins ( figure 2 A). Biopsy showed typical TA.

[0037] Use four layers of gauze moistened with 0.5% (g / mL) timolol maleate (0.5% timolol maleate eye drops, purchased from Wuhan Wujing Pharmaceutical Co., Ltd.) to moisten the lesion, Twice a day for external use for 6 months. The skin lesions on the neck were significantly improved, the skin lesions became flat, and the color became darker ( figure 2B-C). The treatment was well tolerated with no significant side effects. The lesion disappeared completely, and there was no recurrence after 12 months of follow-up after drug withdrawal.

Embodiment 3

[0039] In order to further investigate the effectiveness of timolol in the treatment of TA. The inventors of the present application collected 11 children with plexiform hemangioma (Tufted Angioma, TA) who visited the Department of Dermatology, Children's Hospital from October 2014 to October 2018. All cases were TA that occurred in the skin and were confirmed clinically and pathologically. All children were treated with topical timolol maleate and achieved good results. The specific experimental process and results are as follows:

[0040] 1. Materials and methods

[0041] 1. General information: From October 2014 to October 2018, 11 children with plexiform hemangioma who visited the Department of Dermatology were selected as the research objects, including 9 males and 2 females, aged 6 months to 10 years, and the lesions were located in Head, face and neck in 2 cases, limbs in 5 cases, and trunk in 4 cases. All patients had pain in 5 cases.

[0042] 2. Method: medical g...

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Abstract

The invention relates to an application of timolol or salts thereof to preparation of a medicine for preventing and / or treating plexiform angioma. The timolol or the salts thereof are used for treating plexiform angioma in a local coating manner, any wounds are not generated, the medicine is simple to use, good in treatment tolerance and high in curing rate and plexiform angioma cannot recur afterbeing healed.

Description

[0001] Cross References to Related Applications [0002] This application claims the priority of Chinese patent application 201910593315.4 filed on June 26, 2019. technical field [0003] The invention relates to the technical field of medicine, in particular to the use of timolol or a salt thereof in the preparation of medicaments for preventing and / or treating plexiform hemangioma. Background technique [0004] Tufted Angioma (Tufted Angioma, TA) is a rare benign vascular tumor, also known as hemangioblastoma, hyperplastic hemangioma, progressive capillary hemangioma. First reported by Wilson-Jones and Orkin. TA is more common in children and adolescents, and the onset is more common before the age of 5, with 25% appearing before the age of 1, but there are also reported cases in adults, and the onset is less than 10% after the age of 50. There is no gender difference and familial tendency of this disease. [0005] The clinical manifestations of TA are diverse, and ski...

Claims

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Application Information

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IPC IPC(8): A61K31/5377A61K9/06A61P35/00
CPCA61K9/0014A61K9/06A61K31/5377A61P35/00
Inventor 马琳张斌张楠尉莉李丽邱磊
Owner BEIJING CHILDRENS HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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