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Application of medicine in preparation of drugs for reducing muscle toxicity of statins

A technology of myotoxicity and drugs, which is applied in the application field of drugs in the preparation of drugs that reduce the myotoxicity of statins, can solve the problems of undisclosed application of statins to myotoxicity, and achieve the purpose of promoting sports rehabilitation, reducing skeletal muscle damage, Effects of Improving Medication Adherence

Active Publication Date: 2020-10-16
SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned patent does not disclose the application of the drug in reducing the myotoxicity of statins

Method used

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  • Application of medicine in preparation of drugs for reducing muscle toxicity of statins
  • Application of medicine in preparation of drugs for reducing muscle toxicity of statins
  • Application of medicine in preparation of drugs for reducing muscle toxicity of statins

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] The drug tablet for reducing the myotoxicity of statins is made of the following raw materials in parts by weight:

[0055]

[0056] The preparation method of the medicine tablet comprises the following steps: taking ginseng, coptis, vinegar corydalis, hawthorn and half the amount of astragalus in the raw materials, pulverizing them into fine powder, and decocting the remaining eight-flavored raw materials and the remaining astragalus with water twice , 2 hours for the first time, 1.5 hours for the second time, combine the decoction, filter, and when the filtrate is concentrated to 90°C, the relative density is 1.06-1.12, let it cool, add double the amount of ethanol to precipitate, take the supernatant, and recover Ethanol, and concentrated to 90 ° C relative density of 1.20 ~ 1.22 paste, mixed with the above powder, made into granules, dried, compressed into 1000 tablets (small tablets), sugar-coated or film-coated tablets, or compressed into 500 tablets ( Large pi...

Embodiment 2

[0059] The drug capsule for reducing the myotoxicity of statins is made of the following raw materials in parts by weight:

[0060]

[0061]

[0062] The preparation method of the drug capsule comprises the following steps: taking ginseng, coptis, vinegar corydalis, hawthorn and half of the astragalus in the raw materials, pulverizing them into fine powder, and decocting the remaining eight-flavored raw materials and the remaining astragalus twice with water , 2 hours for the first time, 1.5 hours for the second time, combine the decoction, filter, and when the filtrate is concentrated to 90°C, the relative density is 1.06-1.12, let it cool, add double the amount of ethanol to precipitate, take the supernatant, and recover Ethanol, and concentrated to a clear paste with a relative density of 1.20 to 1.22 at 90°C, mixed with the above-mentioned medicinal powder, and made into capsules.

[0063] For the preparation of drugs for reducing the muscle toxicity of statins, the ...

Embodiment 3

[0065] The drug granules used to reduce the myotoxicity of statins are made of the following raw materials in parts by weight:

[0066]

[0067] The preparation method of the drug granules comprises the following steps: taking ginseng, coptis, vinegar corydalis, hawthorn and half of astragalus in the raw materials, pulverizing them into fine powder, decocting the remaining eight-flavored raw materials and the remaining astragalus with water twice , 2 hours for the first time, 1.5 hours for the second time, combine the decoction, filter, and when the filtrate is concentrated to 90°C, the relative density is 1.06-1.12, let it cool, add double the amount of ethanol to precipitate, take the supernatant, and recover Ethanol, and concentrated to a clear paste with a relative density of 1.20 to 1.22 at 90°C, mixed with the above-mentioned medicinal powder to make granules.

[0068] It is used for preparing the medicine for reducing the muscular toxicity of statins, the statins is ...

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Abstract

The invention discloses application of a medicine in preparation of drugs for reducing the muscle toxicity of statins. Experimental results show that a heart-nourishing tablet can reduce statins related skeletal muscle injury and improve exercise capacity by enhancing mitochondrial activity, improving oxidative stress and inhibiting myolysis of ApoE- / -mice fed with high fat in exercise training, and the effect is remarkable.

Description

technical field [0001] The invention relates to a new application of a medicine, in particular, the invention relates to the application of a medicine in the preparation of a medicine for reducing the myotoxicity of statins, which belongs to the field of traditional Chinese medicine application. Background technique [0002] 3-Hydroxy-3-methylglutathione coenzyme A (HMG-CoA) reductase inhibitors (statins) are commonly used drugs for the treatment and prevention of cardiovascular diseases. Statin intolerance is the inability to tolerate doses of statins adequate to reduce cardiovascular risk, which may be caused by statin-related side effects. The main side effect of statins is muscle-related myopathy, usually defined as muscle pain, tenderness, or weakness, accompanied by large increases in blood creatine kinase concentrations. Statin-induced myopathy ranges from 1-5% to 15-20% of clinical trials and can be fatal in severe cases. In other settings (for example, in combinat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61P21/00A61P9/00A61K31/366
CPCA61K36/481A61K36/344A61K36/537A61K36/488A61K36/296A61K36/734A61K36/804A61K36/232A61K36/718A61K36/66A61K36/074A61K36/258A61K36/484A61P21/00A61P9/00A61K31/366A61K2300/00
Inventor 沈晓燕叶冠吴若铭洪毅高莉
Owner SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
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