Application of a drug in the preparation of a drug for reducing statin muscle toxicity
A technology of myotoxicity and drugs, which is applied in the application field of drugs in the preparation of drugs to reduce the myotoxicity of statins, can solve the problems of undisclosed application of statins to myotoxicity, and achieve the purpose of promoting sports rehabilitation, improving the mechanism of action, increasing The effect of exercise tolerance
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Embodiment 1
[0054] The drug tablet for reducing the muscle toxicity of statins is made from the following raw materials by weight:
[0055]
[0056] The preparation method of the pharmaceutical tablet comprises the following steps: taking ginseng, Coptis chinensis, Vinegar Corydalis, Hawthorn and half of Astragalus in the crude drug, pulverizing it into fine powder, adding the remaining eight-flavor crude drug and the remaining Astragalus and decocting twice with water , 2 hours for the first time, 1.5 hours for the second time, combined decoction, filtered, the relative density of the filtrate was 1.06 to 1.12 when the filtrate was concentrated to 90 ° C, allowed to cool, doubled the amount of ethanol to precipitate, took the supernatant, recovered Ethanol, and concentrated to a clear paste with a relative density of 1.20 to 1.22 at 90 ° C, mixed with the above-mentioned medicinal powder, made into granules, dried, compressed into 1000 tablets (small tablets), sugar-coated or film-coat...
Embodiment 2
[0059] The medicinal capsule for reducing the muscle toxicity of statins is made from the following raw materials by weight:
[0060]
[0061]
[0062] The preparation method of the pharmaceutical capsules comprises the following steps: taking ginseng, Coptis chinensis, vinegar Corydalis, hawthorn and half of the astragalus in the raw material medicine, crushing them into fine powder, adding the remaining eight medicinal materials and the remaining astragalus root and decocting twice with water , 2 hours for the first time, 1.5 hours for the second time, combined decoction, filtered, the relative density of the filtrate was 1.06 to 1.12 when the filtrate was concentrated to 90 ° C, allowed to cool, doubled the amount of ethanol to precipitate, took the supernatant, recovered ethanol, and concentrated to a clear paste with a relative density of 1.20-1.22 at 90°C, mixed with the above-mentioned medicinal powder to prepare capsules.
[0063] For the preparation of a medicin...
Embodiment 3
[0065] The drug granules for reducing the muscle toxicity of statins are made from the following raw materials by weight:
[0066]
[0067] The preparation method of the medicinal granules comprises the following steps: taking ginseng, Coptis chinensis, Vinegar Corydalis, hawthorn and half of Astragalus in the crude drug, pulverizing them into fine powder, and boiling the remaining eight-flavor crude drugs and remaining Astragalus twice with water , 2 hours for the first time, 1.5 hours for the second time, combined decoction, filtered, the relative density of the filtrate was 1.06 to 1.12 when the filtrate was concentrated to 90 ° C, allowed to cool, doubled the amount of ethanol to precipitate, took the supernatant, recovered ethanol, and concentrated to a clear paste with a relative density of 1.20-1.22 at 90°C, mixed with the above-mentioned medicinal powder to prepare granules.
[0068] For preparing a medicine for reducing the muscle toxicity of a statin, the statin i...
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