Traditional Chinese medicine composition for treating oral mucosal diseases and application thereof

Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating oral mucosal diseases and application thereof.The traditional Chinese medicine composition contains radix bupleuri, honeysuckles, radix scutellariae, radix puerariae, herba schizonepetae, artemisia apiacea, fructus forsythiae and other traditional Chinese medicinal materials, and the traditional Chinese medicinal materials are prepared into a medicinal preparation. Animal model tests find that the traditional Chinese medicine composition hasa remarkable curative effect on oral mucosal diseases, especially recurrent oral ulceration, the preparation process of the preparation is simple, and large-scale production of an amplification process has been carried out.

Description

technical field

[0001] The invention belongs to the technical field of medicine and relates to a new application of a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating oral mucosal diseases and its application. Background technique

[0002] In oral mucosal diseases, recurrent oral ulcers rank first in the incidence of the disease. According to relevant epidemiological investigations, 20% of the population in my country suffers from oral ulcers at least once a year. Regardless of age and gender, oral ulcers may occur in any group. This disease has seriously affected people's diet, speech, and reduced quality of life in real life.

[0003] Oral ulcer, commonly known as "mouth sore", is a common ulcerative injury disease that occurs in the oral mucosa, and is more common in the inner lip, tongue, tongue abdomen, buccal mucosa, vestibular groove, soft palate and other parts.

[0004] At present, oral mucosal disea...

Examples

Embodiment 1

[0071]

[0072] For the above eleven flavors, take bitter almonds and crush them into coarse particles, mix with the seven flavors of Bupleurum, honeysuckle, Artemisia annua, forsythia, Nepeta, mint, and Houttuynia cordata, soak in water for 1 hour, heat and distill, collect the distillate for redistillation, Collect the heavy distilled liquid and store it in another container. Combine the medicinal dregs with the three flavors of Scutellaria baicalensis, Pueraria root and Platycodon grandiflorum, add water and decoct three times for 2 hours each time, combine the decoction with the above-mentioned distilled medicinal liquid, filter, concentrate the filtrate, add ethanol, Stir well, refrigerate for 24 hours, take the supernatant to recover ethanol under reduced pressure, concentrate, add the above-mentioned double distilled liquid, and finally make tablets directly or by adding pharmaceutically acceptable excipients through conventional procedures.

Embodiment 2

[0074]

[0075] For the above eleven flavors, take bitter almonds and crush them into coarse particles, mix with the seven flavors of Bupleurum, honeysuckle, Artemisia annua, forsythia, Nepeta, mint, and Houttuynia cordata, soak in water for 1 hour, heat and distill, collect the distillate for redistillation, Collect the heavy distilled liquid and store it in another container. Combine the medicinal dregs with the three flavors of Scutellaria baicalensis, Pueraria root and Platycodon grandiflorum, add water and decoct three times for 2 hours each time, combine the decoction with the above-mentioned distilled medicinal liquid, filter, concentrate the filtrate, add ethanol, Stir well, refrigerate for 24 hours, take the supernatant to recover ethanol under reduced pressure, concentrate, add the above red distillate, and finally make granules directly or by adding pharmaceutically acceptable excipients through conventional procedures.

Embodiment 3

[0077]

[0078] For the above eleven flavors, take bitter almonds and crush them into coarse particles, mix them with seven flavors such as Bupleurum, honeysuckle, Artemisia annua, forsythia, Nepeta, mint, and Houttuynia cordata, soak in water for 1 hour, heat and distill, collect the distillate for redistillation , collect the heavy distilled liquid, store it in another container, combine the dregs with Scutellaria baicalensis, Pueraria root, and Campanulaceae three flavors, add water to decoct three times, each time for 2 hours, combine the decoction with the above-mentioned distilled medicinal liquid, filter, concentrate the filtrate, add ethanol , stir well, refrigerate for 24 hours, take the supernatant to recover ethanol under reduced pressure, concentrate, add the above red distillate, and finally make capsules directly or by adding pharmaceutically acceptable excipients through conventional procedures.

technical field

[0001] The invention belongs to the technical field of medicine and relates to a new application of a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating oral mucosal diseases and its application. Background technique

[0002] In oral mucosal diseases, recurrent oral ulcers rank first in the incidence of the disease. According to relevant epidemiological investigations, 20% of the population in my country suffers from oral ulcers at least once a year. Regardless of age and gender, oral ulcers may occur in any group. This disease has seriously affected people's diet, speech, and reduced quality of life in real life.

[0003] Oral ulcer, commonly known as "mouth sore", is a common ulcerative injury disease that occurs in the oral mucosa, and is more common in the inner lip, tongue, tongue abdomen, buccal mucosa, vestibular groove, soft palate and other parts.

[0004] At present, oral mucosal disea...

Examples

Embodiment 1

[0071]

[0072] For the above eleven flavors, take bitter almonds and crush them into coarse particles, mix with the seven flavors of Bupleurum, honeysuckle, Artemisia annua, forsythia, Nepeta, mint, and Houttuynia cordata, soak in water for 1 hour, heat and distill, collect the distillate for redistillation, Collect the heavy distilled liquid and store it in another container. Combine the medicinal dregs with the three flavors of Scutellaria baicalensis, Pueraria root and Platycodon grandiflorum, add water and decoct three times for 2 hours each time, combine the decoction with the above-mentioned distilled medicinal liquid, filter, concentrate the filtrate, add ethanol, Stir well, refrigerate for 24 hours, take the supernatant to recover ethanol under reduced pressure, concentrate, add the above-mentioned double distilled liquid, and finally make tablets directly or by adding pharmaceutically acceptable excipients through conventional procedures.

Embodiment 2

[0074]

[0075] For the above eleven flavors, take bitter almonds and crush them into coarse particles, mix with the seven flavors of Bupleurum, honeysuckle, Artemisia annua, forsythia, Nepeta, mint, and Houttuynia cordata, soak in water for 1 hour, heat and distill, collect the distillate for redistillation, Collect the heavy distilled liquid and store it in another container. Combine the medicinal dregs with the three flavors of Scutellaria baicalensis, Pueraria root and Platycodon grandiflorum, add water and decoct three times for 2 hours each time, combine the decoction with the above-mentioned distilled medicinal liquid, filter, concentrate the filtrate, add ethanol, Stir well, refrigerate for 24 hours, take the supernatant to recover ethanol under reduced pressure, concentrate, add the above red distillate, and finally make granules directly or by adding pharmaceutically acceptable excipients through conventional procedures.

Embodiment 3

[0077]

[0078] For the above eleven flavors, take bitter almonds and crush them into coarse particles, mix them with seven flavors such as Bupleurum, honeysuckle, Artemisia annua, forsythia, Nepeta, mint, and Houttuynia cordata, soak in water for 1 hour, heat and distill, collect the distillate for redistillation , collect the heavy distilled liquid, store it in another container, combine the dregs with Scutellaria baicalensis, Pueraria root, and Campanulaceae three flavors, add water to decoct three times, each time for 2 hours, combine the decoction with the above-mentioned distilled medicinal liquid, filter, concentrate the filtrate, add ethanol , stir well, refrigerate for 24 hours, take the supernatant to recover ethanol under reduced pressure, concentrate, add the above red distillate, and finally make capsules directly or by adding pharmaceutically acceptable excipients through conventional procedures.

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