Application of USP7 inhibitor in medicine for treating ABC-DLBCL

A technology of inhibitors and small molecule inhibitors, applied in the field of medicine, to achieve the effect of improving people's livelihood and society, good application prospects and market competitiveness

Inactive Publication Date: 2020-10-30
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few reports on the role of USP7 protein in lymphoma

Method used

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  • Application of USP7 inhibitor in medicine for treating ABC-DLBCL
  • Application of USP7 inhibitor in medicine for treating ABC-DLBCL
  • Application of USP7 inhibitor in medicine for treating ABC-DLBCL

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Experimental program
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Embodiment 1

[0036] A kind of application of USP7 inhibitor in the treatment of ABC-DLBCL medicine, the steps are:

[0037] The first step, the relationship between USP7 expression and ABC-type DLBCL: To determine whether USP7 is related to ABC-type DLBCL, first study the expression of USP7 in DLBCL cell lines, and use Western blot to detect USP7 in ABC-type DLBCL and GCB-type DLBCL cell lines Protein expression, compared with GCB-DLBCL subtype, USP7 is highly expressed in ABC-type DLBCL, this expression difference confirms that USP7 is involved in the occurrence of ABC-DLBCL, and then through database analysis, compared with para-cancerous tissue, USP7 is highly expressed in tumor tissue Express.

[0038] Such as figure 1 As shown, the expression level of USP7 in DLBCL: Panel A: TCGA database analysis showed that in 31 tumor tissues, the expression of USP7 in cholangiocarcinoma, thymoma and DLBCL was higher than that in normal tissues; Panel B: compared with the control group , USP7 is...

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Abstract

The invention discloses an application of a USP7 inhibitor in a medicine for treating ABC-DLBCL. The expression condition of the USP7 in a DLBCL cell line is studied; through database analysis, a USP7small-molecule inhibitor is used for inhibiting USP7 activity; the influence of ABC type DLBCL cell proliferation, PI staining and flow cytometry on cell apoptosis and the influence of cell apoptosison an ABC type DLBCL BCR signal path by a CCK-8 method can be observed; USP7 is a ubiquitin specific protease which is most widely researched at present; researches show that USP7 participates in regulating the activity and functions of various protein substrates of cells, USP7 expression abnormality or activity change plays an important role in occurrence and development of diseases and tumors,and USP7 has good application prospects and market competitiveness and has a good promotion effect on improvement of people's livelihood and society in China.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a USP7 inhibitor in the treatment of ABC-DLBCL. Background technique [0002] Lymphoma is a kind of monoclonal proliferative disease originating from the lymphatic hematopoietic system, divided into Hodgkin's lymphoma (Hodgkin's lymphoma, HL) and non-Hodgkin's lymphoma (NHL), my country's annual About 84,000 people are diagnosed with lymphoma. Non-Hodgkin's lymphoma (NHL) is a group of hematological malignancies with obvious heterogeneity, which can be divided into B-cell NHL and T / NK-cell NHL according to histopathological types. In B-NHL, the most common subtype is diffuse large B-cell lymphoma (DLBCL), accounting for 45.8% of NHL. With the widespread use of rituximab-based immunochemotherapy (R-CHOP) in the treatment of DLBCL, more than half of the patients are cured, but more than 30% of the patients still face the risk of recurrence and are not sensi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61P35/00C12Q1/686G01N15/14G01N21/64G01N33/68
CPCA61K45/00A61P35/00G01N33/68C12Q1/686G01N21/64G01N15/14
Inventor 吴圆圆范义辉
Owner NANTONG UNIVERSITY
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