PH responsive drug-loaded nanoparticle
A drug-loaded nano-responsive technology, which is applied in the fields of biomedicine and polymer nanomaterials, can solve the problem of few drug-loaded nanoparticles, and achieve the effects of excellent drug release efficiency, excellent stability, and simple process
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Embodiment 1
[0066] Example 1: A pH-responsive drug-loaded nanoparticle:
[0067] This embodiment provides a pH-responsive drug-loaded nanoparticle. The drug-loaded nanoparticle uses a quaternary ammonium salt-modified pectin / polycaprolactone graft copolymer and a drug to form a core structure. It is a shell structure, in which the degree of esterification of pectin is 58%.
[0068] The pH-responsive drug-loaded nanoparticles described in this example were prepared by the following method:
[0069] 1) Preparation of quaternary ammonium salt modified pectin / polycaprolactone graft copolymer:
[0070] 1.1) Mix 8g of pectin and 100g of 1-allyl-3-methylimidazolium chloride salt, raise the temperature to 75°C, and ultrasonically (ultrasonic frequency is 20kHz, ultrasonic power density 0.45W / cm 2 ) to disperse for 15 minutes to make it fully dissolve to obtain a pectin solution;
[0071] 1.2) Add 64g of L-lactide and 7g of 4-dimethylaminopyridine to the pectin solution, raise the temperature t...
Embodiment 2
[0083] Example 2: Another pH-responsive drug-loaded nanoparticle:
[0084] This example provides another pH-responsive drug-loaded nanoparticle. The preparation method is basically the same as Example 1, except that in this example, quaternary ammonium salt modified pectin / polycaprolactone grafted In step 1) of the copolymer, the degree of esterification of pectin is 40%.
Embodiment 3
[0085] Example 3: Another pH-responsive drug-loaded nanoparticle:
[0086] This example provides another pH-responsive drug-loaded nanoparticle. The preparation method is basically the same as Example 1, except that in this example, quaternary ammonium salt modified pectin / polycaprolactone grafted In step 1) of the copolymer, the degree of esterification of pectin is 55%.
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