PH responsive drug-loaded nanoparticle

A drug-loaded nano-responsive technology, which is applied in the fields of biomedicine and polymer nanomaterials, can solve the problem of few drug-loaded nanoparticles, and achieve the effects of excellent drug release efficiency, excellent stability, and simple process

Inactive Publication Date: 2020-10-30
嘉兴市轩禾园艺技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pectin is a natural polymer compound. Gum is an acidic polysaccharide in plants. The main chain is a homopolysaccharide composed of negatively charged galacturonic acid. It is non-toxic, easy to degrade and biocompatible. It can be used for the preparation of drug-loaded nanoparticles, but there are few studies and related reports on the preparation of drug-loaded nanoparticles using pectin as a raw material, and the method still needs to be improved and perfected.

Method used

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Examples

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Effect test

Embodiment 1

[0066] Example 1: A pH-responsive drug-loaded nanoparticle:

[0067] This embodiment provides a pH-responsive drug-loaded nanoparticle. The drug-loaded nanoparticle uses a quaternary ammonium salt-modified pectin / polycaprolactone graft copolymer and a drug to form a core structure. It is a shell structure, in which the degree of esterification of pectin is 58%.

[0068] The pH-responsive drug-loaded nanoparticles described in this example were prepared by the following method:

[0069] 1) Preparation of quaternary ammonium salt modified pectin / polycaprolactone graft copolymer:

[0070] 1.1) Mix 8g of pectin and 100g of 1-allyl-3-methylimidazolium chloride salt, raise the temperature to 75°C, and ultrasonically (ultrasonic frequency is 20kHz, ultrasonic power density 0.45W / cm 2 ) to disperse for 15 minutes to make it fully dissolve to obtain a pectin solution;

[0071] 1.2) Add 64g of L-lactide and 7g of 4-dimethylaminopyridine to the pectin solution, raise the temperature t...

Embodiment 2

[0083] Example 2: Another pH-responsive drug-loaded nanoparticle:

[0084] This example provides another pH-responsive drug-loaded nanoparticle. The preparation method is basically the same as Example 1, except that in this example, quaternary ammonium salt modified pectin / polycaprolactone grafted In step 1) of the copolymer, the degree of esterification of pectin is 40%.

Embodiment 3

[0085] Example 3: Another pH-responsive drug-loaded nanoparticle:

[0086] This example provides another pH-responsive drug-loaded nanoparticle. The preparation method is basically the same as Example 1, except that in this example, quaternary ammonium salt modified pectin / polycaprolactone grafted In step 1) of the copolymer, the degree of esterification of pectin is 55%.

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Abstract

The invention belongs to the technical field of biological medicines and polymer nano-materials, and particularly relates to a pH-responsive drug-loaded nanoparticle and a preparation method thereof.According to the preparation method, a core layer with pH response is obtained through electrostatic interaction of a quaternary ammonium salt modified pectin/polycaprolactone grafted copolymer and drug adriamycin, and a disulfide crosslinked shell layer is obtained through mercaptopectin under the action of hydrogen peroxide, so that drug-loaded nanoparticles with pH response are prepared; a shell-core structure enables the nanoparticle to have high stability, leakage of the drug can be effectively reduced, long-acting release is achieved, the quaternary ammonium salt unit in the core is pH-sensitive, the nanoparticle is subjected to conformational change in the environment with low pH, active ingredients of the drug in the nanoparticle are released, and the drug has targeting property.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and macromolecular nanomaterials, and in particular relates to a pH-responsive drug-loaded nanoparticle and a preparation method thereof. Background technique [0002] A drug carrier refers to a system that can change the way a drug enters the human body and its distribution in the body, controls the release rate of the drug, and delivers the drug to the target organ. Nano-drug carrier has the following advantages: (1) improves the solubility of medicine; (2) can avoid direct contact of medicine and pepsin, improves the stability of medicine; (3) promotes the absorption of medicine; (4) keeps drug concentration stable; ( 5) Realize the intelligent release of drugs and reduce the toxic and side effects of drugs on normal tissues. Common nano-drug carriers mainly include liposomes, nanoparticles, and nanomicelles. Among them, nanoparticles are usually spherical structures with a particle size ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/61A61K47/59A61K47/69A61K31/704A61P35/00C08G63/91C08G63/08C08B37/06
CPCA61K31/704A61K47/593A61K47/61A61K47/6939A61P35/00C08B37/0045C08G63/08C08G63/912
Inventor 不公告发明人
Owner 嘉兴市轩禾园艺技术有限公司
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