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Group of markers for predicting metastasis risk of nasopharyngeal carcinoma and application thereof

A marker and nasopharyngeal carcinoma technology, applied in the field of biomarkers, can solve the problems of differences, high toxicity of chemotherapy, inability to completely and accurately predict the metastasis risk and prognosis of nasopharyngeal carcinoma patients, and achieve accurate prediction and good clinical outcomes. The effect of medication

Active Publication Date: 2020-11-27
SUN YAT SEN UNIV CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, patients with the same stage and similar levels of EBV before treatment, after receiving the same standard treatment, there is also a large difference in whether metastasis occurs
Obviously, TNM clinical staging and pre-treatment EBV-DNA levels based on anatomical information alone cannot accurately predict the metastasis risk and prognosis of patients with nasopharyngeal carcinoma
At the same time, TNM clinical staging and pre-treatment EBV-DNA levels cannot be used to guide individualized medication, resulting in the current chemotherapy efficacy rate for patients with metastatic nasopharyngeal carcinoma being only 40-65%, and chemotherapy toxicity is large

Method used

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  • Group of markers for predicting metastasis risk of nasopharyngeal carcinoma and application thereof
  • Group of markers for predicting metastasis risk of nasopharyngeal carcinoma and application thereof
  • Group of markers for predicting metastasis risk of nasopharyngeal carcinoma and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Example 1 Screening of markers

[0031] Proteins associated with metastasis-free survival in nasopharyngeal carcinoma identified:

[0032] The inventors used the custom-made Raybiotech Quantibody Array protein chip technology platform to detect these 50 differentially expressed genes in 226 specimens, and screened out 18 plasma proteins that were associated with distant metastasis-free survival of nasopharyngeal carcinoma by single-factor Cox analysis.

[0033] Discovery of metastatic protein markers in nasopharyngeal carcinoma:

[0034] The inventors used the LASSO-Cox model to further select 5 proteins to form a set of markers, including: SLAMF5, ESM-1, MMP-8, INSR, Serpin A5, and named these 5 protein markers PSDM (protein-based signature for distant metastasis in LA-NPC, locally advanced nasopharyngeal carcinoma distant metastasis protein signature).

[0035] The scoring formula for the markers to predict the risk of nasopharyngeal carcinoma metastasis is:

[003...

Embodiment 2

[0038] Efficacy test of embodiment 2 protein marker

[0039] The inventors then compared the performance of the combination of protein markers in predicting distant metastasis of nasopharyngeal carcinoma with that of a single protein, N stage, and EBV-DNA levels. Time-dependent ROC curves showed that the combination of protein markers outperformed each individual protein at the 5-year time point (C-index: 0.76, 95% CI 0.67-0.85; P image 3 A), while the time-dependent AUC analysis showed that in the continuous 7-year time span, the performance of the protein marker combination was always better than that of each individual protein (P image 3 B). Similarly, we also found that protein markers were more effective in predicting NPC metastasis than N stage and EBV-DNA level before treatment at the 5-year time point and continuous time (P image 3 C-D).

[0040] In addition, the inventors also analyzed whether DMGN can predict the benefit of docetaxel + cisplatin + 5-fluorouracil (TPF...

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Abstract

The invention discloses a group of plasma protein markers for predicting nasopharyngeal carcinoma metastasis risk and application thereof. The markers comprise SLAMF5 (Sequence Location Assisted Middle Function 5), ESM-1 (Enhanced Science Model), MMP-8 (Methyl Methyl Pyrrolidone 8), INSR (Induced Sequence Regulator) and Serpin A5. The protein label formed by expression of the five proteins can reflect the biological specificity of a nasopharyngeal carcinoma patient, the metastasis risk and prognosis of the nasopharyngeal carcinoma patient can be predicted accurately and clinical medication can be better guided, and the prediction efficiency of the protein label on non-distant survival is superior to that of a single protein, a tumor N stage and an EBV-DNA level.

Description

technical field [0001] The present invention relates to the technical field of biomarkers, more specifically, to a group of markers for predicting the risk of metastasis of nasopharyngeal carcinoma and its application. Background technique [0002] Nasopharyngeal carcinoma (NPC) is an aggressive malignant tumor of the head and neck. About 40% of the cases in the world occur in my country, especially in southern my country such as Guangdong Province. The incidence of nasopharyngeal carcinoma is high in young adults, and 70% of the patients are in the middle and late stage when they first see a doctor, which brings a heavy burden to the patient's family and poses a serious threat to the life and health of our people. In recent years, with the application of modern imaging technology, advances in radiotherapy technology, and the application of combined radiotherapy and chemotherapy strategies, the local control rate of nasopharyngeal carcinoma has been significantly improved, a...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N33/68
CPCG01N33/57407G01N33/57488G01N33/6893G01N2800/50
Inventor 马骏柳娜黎映琴梁叶琳唐玲珑陈磊毛燕萍何庆梅杨晓静
Owner SUN YAT SEN UNIV CANCER CENT
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