Risk assessment for phenytoin-induced adverse drug reactions

a risk assessment and drug technology, applied in the field of risk assessment of adverse drug reactions in response to phenytoin, can solve the problems of delayed clearance and severe cutaneous adverse reactions of phenytoin
US20150225788A1Inactive Publication Date: 2015-08-13CHANG GUNG MEDICAL FOUND CHANG GUNG MEMORIAL HOSPITAL AT KEELUNG
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
CHANG GUNG MEDICAL FOUND CHANG GUNG MEMORIAL HOSPITAL AT KEELUNG
Publication Date
2015-08-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

A method of predicting the risk of a patient for developing phenytoin-induced adverse drug reactions (ADRs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug reactions with eosinophilia and systemic symptoms (DRESS) is disclosed. Genetic polymorphisms of CYP2C genes (including rs1057910 (CYP2C9*3) and rs3758581 on CYP2C19), and HLA alleles (including HLA-B*1502, HLA-B*1301, and HLA-B*5101) can predict adverse reactions caused by phenytoin or fosphenytoin. Accordingly, the present invention provides a kit to assess the risk of a patient for developing adverse reactions in response to phenytoin-related drugs, which comprises the determination of the presence of a specific allele selected from the group consisting of rs1057910 (CYP2C9*3), rs3758581 on CYP2C19, HLA-B*1502, HLA-B*1301, and HLA-B*5101, wherein the presence of at least one allele is indicative of a risk for the adverse drug reactions.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation-in-part of U.S. application Ser. No. 13 / 323,515, filed Dec. 12, 2011, entitled “RISK ASSESSMENT FOR PHENYTOIN-INDUCED ADVERSE DRUG REACTIONS”. The entire teachings of the above application are incorporated herein by reference.FIELD OF THE INVENTION

[0002] The present invention is related to a method for predicting the risk of a patient for adverse drug reactions, and more particularly to a risk assessment for developing adverse drug reactions in response to phenytoin.BACKGROUND OF THE INVENTION

[0003] Adverse drug reactions (abbreviated ADRs) are expressions that describe harm associated with the use of given medication at a normal dosage. Drug hypersensitivity is a common adverse event during medical treatments and contributes to about 20% of reported ADRs. These hypersensitivity reactions may present from mild skin rash (MPE) to life-threatening drug reaction with eosinophilia and systemic symptoms (DRESS)...

Claims

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