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Device and method for measuring width of crystallization metastable region of micro-scale flow system

A metastable zone, micro-scale technology, applied in the direction of measuring devices, material crystallization, test crystals, etc., can solve the problem of inability to measure the metastable zone of the microscale flow system, the inability to measure the width of the crystal metastable zone, and the size of the microchannel, etc. problems, to achieve the effect of easy change of operating conditions, convenient cleaning, and simple process control

Active Publication Date: 2021-01-01
SICHUAN UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the conductivity measurement device in this method The size of the probe is too large compared to the microchannel, and it cannot be inserted into the microchannel for further investigation. row contact measurement , it is impossible to measure the metastable region of the micro-scale flow system
[0005] It can be seen that none of the methods for measuring the metastable zone in the prior art can solve the problem of measuring the width of the crystallized metastable zone in the flow system at the micro scale.

Method used

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  • Device and method for measuring width of crystallization metastable region of micro-scale flow system
  • Device and method for measuring width of crystallization metastable region of micro-scale flow system

Examples

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Embodiment 1

[0031] In this embodiment, the microchannel 6 is a quartz glass tube with an inner diameter of 0.9 mm, an outer diameter of 1.5 mm, and a length of 23 cm. The device for measuring the width of the crystallization metastable zone in the microscale flow system is as follows: figure 1 As shown, it includes a temperature control system, a microscope 4 , a camera 5 , a computer 3 , and a syringe pump 2 . The temperature control system is composed of a constant temperature circulating water bath 10, a first thermal insulation jacket 7-1, a second thermal insulation jacket 7-2 and a temperature sensor 1. The length of the first thermal insulation jacket 7-1 is 17.5cm, and the suit In the section of the liquid inlet end of the microchannel, the second thermal insulation jacket 7-2 is set on the section of the liquid outlet end of the microchannel, and the spacing between the first thermal insulation jacket and the second thermal insulation jacket is 1 cm, and the spacing forms a micr...

Embodiment 2

[0034] In this example, the apparatus described in Example 1 is used to measure the width of the metastable zone when the potassium dihydrogen phosphate aqueous solution reaching saturation at 40° C. flows at a microscale.

[0035] According to the existing potassium dihydrogen phosphate solubility curve, dissolve 33.5g of potassium dihydrogen phosphate crystals (analytical pure) in 100g of deionized water to form an aqueous solution of potassium dihydrogen phosphate that reaches saturation at 40°C, and keep the temperature at 40°C spare.

[0036] The assay steps of the present embodiment are as follows:

[0037] (1) Fix the microchannel 6 equipped with the first thermal insulation jacket 7-1 and the second thermal insulation jacket 7-2 on the stage of the microscope 4, and make the microscope objective lens aim at the microchannel observation section, open and The camera 5 combined with the eyepiece of the microscope 4 observes the inside of the microchannel, and shoots the ...

Embodiment 3

[0042] In this example, the device described in Example 1 was used to measure the width of the metastable zone of the microscale flow system of the potassium dihydrogen phosphate aqueous solution reaching saturation at 40°C.

[0043] According to the existing potassium dihydrogen phosphate solubility curve, dissolve 33.5g of potassium dihydrogen phosphate crystals (analytical pure) in 100g of deionized water to form an aqueous solution of potassium dihydrogen phosphate that reaches saturation at 40°C, and keep the temperature at 40°C spare.

[0044] The assay steps of the present embodiment are as follows:

[0045] (1) Fix the microchannel 6 equipped with the first thermal insulation jacket 7-1 and the second thermal insulation jacket 7-2 on the stage of the microscope 4, and make the microscope objective lens aim at the microchannel observation section, open and The camera 5 combined with the eyepiece of the microscope 4 observes the inside of the microchannel, and shoots th...

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Abstract

The present invention discloses a device for measuring the width of the crystallization metastable region of a micro-scale flow system. The device comprises a temperature control system, a microscope,a camera, a computer and an injection pump, and the temperature control system is composed of a constant-temperature circulating water bath device, a first heat preservation jacket, a second heat preservation jacket and a temperature sensor. According to a method for measuring the width of the crystallization metastable region of the micro-scale flow system, by using the above device, a measuredsolution with the temperature being the initial test temperature and reaching the saturation state at the initial test temperature is injected into a micro-channel at the constant flow rate through the injection pump, and by combining the amplification effect of the microscope on the micro-channel, the camera is adopted to shoot the measured liquid in the micro-channel in real time, the crystallization state of the liquid is captured, the crystallization point temperature is obtained, the difference value between the initial test temperature and the crystallization point temperature is calculated, and the difference value is the width of the crystallization metastable region of the micro-scale flow system of the measured solution. The device and the method provided by the invention providethe quantitative data analysis support for the micro-channel-crystallization coupling technology research.

Description

technical field [0001] The invention belongs to the field of crystallization data measurement, in particular to a device and method for measuring the width of a crystallization metastable zone in a microscale flow system. Background technique [0002] In the chemical and pharmaceutical industries, crystallization, as an effective separation and purification technology, is widely used in the preparation and purification of fine chemicals and biological products. In order to obtain crystal products with required quality indicators, industrial crystallization is generally operated in the crystallization metastable region. The so-called metastable zone refers to the region (range) between the solubility curve and the supersolubility curve of the solution system. The so-called solubility is the quality of the solute dissolved when a solid substance reaches saturation in 100g of solvent at a certain temperature. The so-called Supersolubility is the limit solubility of a solute at...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N25/14G01N21/84
CPCG01N25/147G01N25/145G01N21/84G01N2021/8477G01N2021/8411
Inventor 金央王逸夫任永胜李军李维贾连玉陈明
Owner SICHUAN UNIV
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