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Medicine for preventing and treating ectoparasitic disease of animal and application

A technology for ectoparasites and ectoparasites, which is applied in the direction of drug combinations, medical preparations containing active ingredients, anti-infective drugs, etc., can solve the problems of less research on pharmacological and toxicological properties, so as to improve the acaricidal effect and be suitable for Promote application and synthesize simple effects

Active Publication Date: 2021-02-26
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is derived from microorganisms and can also be synthesized, and the synthesis method is simple. It belongs to coumarin compounds. At present, there are few studies on its pharmacological and toxicological properties.

Method used

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  • Medicine for preventing and treating ectoparasitic disease of animal and application
  • Medicine for preventing and treating ectoparasitic disease of animal and application
  • Medicine for preventing and treating ectoparasitic disease of animal and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Research on the Insecticidal Activity of Coumarin Compounds to Hungry Blood Larvae Longhorn

[0020] 1. Experimental methods and materials

[0021] Starved adult ticks of the long-horned blood tick Haemaphysalis longicornis were collected, and New Zealand big-eared white rabbits were used as hosts for passage, and cultured at 27±2°C, RH≥80%. Experimental test ticks were used only once, after which they were sacrificed by boiling water.

[0022] Experimental grouping: 4-methoxy-2H-chromen-2-one, 7-hydroxy-4-methylcoumarin (hydroxymethylcoumarin) group, scopoletin group, basartene group, imperatorin group, isoimperatorin group.

[0023] Experimental method: According to the filter paper bag method, 50 larvae hatched for 10 days were placed in a 4×4cm filter paper bag. After the medicine was dissolved in 10% DMSO, 0.8ml of the medicine solution was taken to soak the filter paper wrapped with larvae, and 10% DMSO solution was used as the solvent control. After...

Embodiment 2

[0028] Example 2 Acaricide clinical curative effect research

[0029] 1. Experimental grouping and dosage

[0030] 4-methoxy-2H-chromen-2-one drug treatment group: 100μg / mL;

[0031] Binartemisinin drug treatment group: 100μg / mL;

[0032] 1% ivermectin group: 100 μg / mL;

[0033] 2. Experimental method

[0034] Collect the New Zealand big-eared white rabbits that are naturally infected with itch mite from the farm, and select 45 big-eared white rabbits with relatively similar scores according to the grading system (Table 2) of the clinical infection of rabbit itch mite, and divide them into three groups at random. There were 15 rabbits in the same group. Before the experiment, the rabbits suffering from acariasis were not treated with other drugs, and there were no other complications, and there was no significant difference in clinical practice among the three groups. The 4-methoxy-2H-chromen-2-one drug treatment group and the binartemisinide drug treatment group sprayed t...

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Abstract

The invention discloses use of a compound 4-methoxy-2H-chrom-2-one as a medicine for preventing and treating an ectoparasitic disease of an animal. Compared with the traditional medicines, as a parasiticide medicine, the 4-methoxy-2H-chrom-2-one has the following characteristics and advantages that the effect of preventing and treating the ectoparasitic disease of the animal is good and is improved remarkably compared with that of parasiticides in the prior art; the 4-methoxy-2H-chrom-2-one is low in toxicity and safe to environments; and 4-herniarin can be dissolved in a variety of solvents and is easily mixed with other ingredients for killing animal ectoparasites to prepare parasiticides, and thus, the action of improving parasiticide effect can be acted. The invention provides a relatively-safe medicine for killing the animal ectoparasites.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, discloses a new application of a 4-methoxy-2H-chromen-2-one compound, and specifically relates to its application in preventing and treating animal ectoparasitic diseases. Background technique [0002] Animal ectoparasites such as fleas, lice, flies, mosquitoes, ticks and mites can parasitize many types of animals of all ages, leading to a decline in the production performance of sick animals and the quality of livestock products, and even death. According to reports, the spread of African swine fever, a severe infectious disease that seriously affects the production of domestic pigs, is inseparable from ticks and other insects as vectors. Simultaneously, also seriously threaten the health of mankind, every year 100-300 million people are infected with scabies case report worldwide. Animal ectoparasitic diseases not only directly affect the production efficiency and healthy development of anim...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61P33/14
CPCA61K31/366A61P33/14
Inventor 尚小飞苗小楼代立霞潘虎张继瑜李冰
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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