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Composition for fat formation inhibition and body fat reduction, containing hydrangenol as active ingredient

An active ingredient and fat-inhibiting technology, which is applied in the direction of medical preparations containing active ingredients, functions of food ingredients, food ingredients, etc., can solve the problem of not inhibiting fat accumulation

Active Publication Date: 2021-03-19
COSMAX BIO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, there is no research on the mechanism of fat accumulation inhibition of a composition for inhibiting adipogenesis and reducing body fat using hydrangel as an active ingredient

Method used

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  • Composition for fat formation inhibition and body fat reduction, containing hydrangenol as active ingredient
  • Composition for fat formation inhibition and body fat reduction, containing hydrangenol as active ingredient
  • Composition for fat formation inhibition and body fat reduction, containing hydrangenol as active ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Example 1: Manufacture of hydrangea extract containing hydrangeol

[0090] The hydrangea extract of the composition of the present invention was produced by the following procedure. First, 20 kg of dried hydrangea (Hydrangea serrata) raw materials and 300 kg of purified water were put into an extraction tank, and extracted under reflux at 100° C. for 5 hours. The extracted sample was filtered through a filter cartridge (10 μm), then concentrated under reduced pressure, and spray-dried to obtain a water-soluble powder.

Embodiment 2

[0091] Example 2: Manufacture of Hydrangenol from Hydrangea Extract

[0092] The extract powder obtained in Example 1 was subjected to gel filtration by using Diaion HP-20. As a developing solvent, 2 L of 30%, 50%, 70%, 100% alcohol and CH 2 Cl 2 - A mixed solution of MeOH (1:1, v / v) was subjected to solvent fractionation and divided into 5 small fractions (392-70EDia1~5). Using methanol as a developing solvent, the small fraction 392-70EDia4 was divided into 7 small fractions (392-70EDia4a~4g) using Sephadex LH-20. Among them, the 392-70EDia4d fraction was recrystallized in methanol to obtain pure amorphous compounds 1 (Hydrangel) single substance.

[0093] The extract powder obtained in Example 1 of the present invention and the hydrangeol obtained in Example 2 were carried out by high performance liquid chromatography (High Performance Liquid Chromatography; HPLC) and ultraviolet-visible light detector (UV / Vis detector). analyze. Using Waters e2695 Series system (Wat...

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Abstract

The present invention relates to a composition for fat formation inhibition and body fat reduction, containing hydrangenol as an active ingredient. A composition of the present invention reduces fat accumulation in fat cells, reduces the phosphorylation of a mammalian target of rapamycin (mTOR), and increases the phosphorylation of forkhead box O1 (FoxO1) so as to ultimately reduce the expressionof peroxisome proliferator-activated receptor gamma (PPAR gamma), thereby inhibiting the formation of triglycerides in adipocytes so as to exhibit anti-obesity effects. Therefore, a composition containing hydrangenol as an active ingredient, disclosed in the present specification, can be effectively used in the field of health functional foods or cosmetics for fat formation inhibition .

Description

technical field [0001] The present invention relates to a composition for suppressing obesity and reducing body fat by reducing the accumulation of fat in mast cells, and more particularly, relates to a composition wherein Hydrangenol inhibits peroxisome proliferation by reducing The expression of Peroxisome proliferator-activated receptor gamma (Peroxisome proliferator-activated receptor gamma) and the reduction of adipocyte differentiation factors inhibit the accumulation and secretion of neutral fat (triglyceride), thereby inhibiting the formation of fat caused by excessive nutrient exposure and Reduce body fat. Background technique [0002] Obesity is a very serious disease for which there is no medically effective treatment although it is rapidly increasing in countries all over the world. The World Health Organization (WHO) stipulates that a body mass index (BMI: Body MassIndex) higher than or equal to 30 is obese. A study published that, as of 2014, not only 13% of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61Q19/06A23L33/10
CPCA23L33/10A61Q19/06A61K36/185A61K8/498A61K8/9789A61K2800/92A23V2002/00A23V2200/332
Inventor 李仙姬申有镜安惠信李璟泰郑暻淑辛智善韩希秀
Owner COSMAX BIO
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