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Degradable photo-thermal/chemotherapy synergistic anti-tumor fiber dressing

An anti-tumor and fiber technology, applied in the field of biomedicine, can solve the problems of low drug load, excessive renal clearance rate, blood circulation instability, etc., and achieve the effect of enhancing hydrophilicity and softness

Pending Publication Date: 2021-03-26
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current photothermal / chemotherapy synergistic anti-tumor technology mostly adopts the method of intravenous injection of drug-loaded photothermal microspheres, which has many limitations, such as low drug load, greatly affected by blood circulation instability, non-lesional Aggregation at sites, excessive renal clearance, and insufficient uptake of tumor cells

Method used

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  • Degradable photo-thermal/chemotherapy synergistic anti-tumor fiber dressing

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] An anti-tumor fiber dressing, the method comprising the steps of:

[0024] (1) Weigh 5g molecular weight of 80,000 PLGA particles to add 30 ml of chloroform and acetone compound solvent (mass ratio 1: 1) to a PLGA spinning liquid, and then add 2.5 g of DOX to formulate a formulated PLGA spinning solution to dissolve and dissolve and Ultrasound dispersion;

[0025] (2) The mixed spinning liquid of step (1) is electrostatically spun, the spinning voltage is 20 kV, the receiving distance is 25 cm, the spinning speed is 0.8 ml / h, the ambient temperature is 25 ° C, the humidity is 50%, Preparation of PLGA composite fiber membranes doped with DOX drugs;

[0026] (3) Immerse the composite fiber membrane of step (2) into a 1 mmol / l DA solution for self-polymerization, the solvent is a Tris-HCl buffer, and the self-polymerization conditions are: light contact air, temperature 25 ° C, pH 7.5, polymerization Time 3H, prepared a composite fiber membrane coated by the PDA;

[0027] ...

Embodiment 2

[0029] An anti-tumor fiber dressing, the method comprising the steps of:

[0030] (1) Weigh 10G molecular weight of 100,000 PLGA particles to add 60 mL of chloroform and acetone compound solvent (mass ratio 1: 1) to PLGA spinning liquid, and then add 5 g of DOX to formulate a preformed PLGA spinning solution to dissolve and ultrasound dispersion;

[0031] (2) The mixed spinning liquid of step (1) is electrostatically spun, the spinning voltage is 23 kV, the receiving distance is 28 cm, the spinning speed is 1.2 ml / h, the ambient temperature is 28 ° C, the humidity is 40%, Preparation of PLGA composite fiber membranes doped with DOX drugs;

[0032] (3) Immerse the composite fiber membrane of step (2) in a solution of 2 mmol / l DA to carry out self-polymerization, the solvent is Tris-HCl buffer, the self-polymerization conditions are: light contact air, temperature 28 ° C, pH 7.8, polymerization Time 4h, prepared a composite fiber membrane coated with a PDA layer;

[0033] (4) Ri...

Embodiment 3

[0035] An anti-tumor fiber dressing, the method comprising the steps of:

[0036] (1) Weighing 8g molecular weight of 120,000 PLGA particles to add 50 mL of chloroform and acetone compound solvent (mass ratio 1: 1) to PLGA spinning liquid, and then add 4 g of DOX to formulate well-prepared PLGA spinning fluid to dissolve and ultrasound dispersion;

[0037] (2) The mixed spinning liquid of step (1) is electrostatically spun, the spinning voltage is 18 kV, the receiving distance is 20 cm, the spinning speed is 1.6 ml / h, the ambient temperature is 18 ° C, the humidity is 60%, Preparation of PLGA composite fiber membranes doped with DOX drugs;

[0038] (3) Immersion of the composite fiber membrane of step (2) in a solution of 1.5 mmol / l DA for self-polymerization, the solvent is Tris-HCl buffer, the self-polymerization conditions: light contact air, temperature 27 ° C, pH 8.0, The polymerization time is 5 h, and the composite fiber membrane coated by the PDA layer is prepared;

[...

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Abstract

The invention provides a degradable photo-thermal / chemotherapy synergistic anti-tumor fiber dressing, and belongs to the technical field of biological medicines. Firstly, a polylactic acid-glycolic acid fiber membrane containing an anti-tumor drug adriamycin is prepared by an electrostatic spinning technology; the prepared composite fiber membrane is immersed into a dopamine-containing solution, and a polydopamine layer with a photo-thermal effect is formed on the surface of the fiber by utilizing dopamine self-polymerization reaction; and finally, the prepared composite fiber membrane is thoroughly cleaned and dried to prepare the degradable photo-thermal / chemotherapy synergistic anti-tumor fiber dressing. The fiber dressing disclosed by the invention has photo-thermal and chemotherapy dual anti-tumor effects at the same time, can realize large-area, long-acting and thorough killing of tumor cells of wounds after tumor excision, can be used for developing novel anti-tumor dressings, and is applied to clinical treatment.

Description

Technical field [0001] The present invention belongs to the field of biopharmaceutical technology, and more particularly to a degradable optical heat / chemotherapy to co-antitumor fiber dressing. Background technique [0002] At present, early cancer is subject to surgery as the main treatment means, but the eradication of tumor cells remaining after tumor resection has been a key issue in clinical treatment. Traditional dressings are mainly based on antibacterial, and it is difficult to meet the application needs of tumor resection wounds. New wound dressings with anti-tumor function are of great significance. [0003] Drug chemotherapy is the main means of tumor treatment, but long-term chemotherapy will not only deepen the patient's toxic side, but will cause tumors to produce drug resistance. Today, tumor combination therapy of photothermal combination chemotherapy is increasingly valued. The photothermal method is to illuminate near-infrared light in the tumor-specific site...

Claims

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Application Information

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IPC IPC(8): A61L15/26A61L15/20A61L15/42A61L15/44A61L15/62
CPCA61L15/26A61L15/20A61L15/42A61L15/44A61L15/62A61L2300/416A61L2300/45C08L67/04C08L79/02
Inventor 李大伟付译鋆张瑜张伟成悦左涵
Owner NANTONG UNIVERSITY
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