One-step synthesis of star-shaped gold nanoparticles based on polyglutamic acid and preparation method thereof

A technology of gold nanoparticles and polyglutamic acid, which is applied in the direction of nanotechnology, nanotechnology, nanotechnology, etc. for materials and surface science, can solve problems such as cumbersome steps, and achieve the reduction of cytotoxicity and the accuracy of particle size and morphology. control, increase dispersion and biocompatibility

Active Publication Date: 2022-06-21
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the synthesis method of the above materials does not require the use of toxic organic solvents and improves the biological stability and biocompatibility, the steps of material synthesis are still cumbersome

Method used

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  • One-step synthesis of star-shaped gold nanoparticles based on polyglutamic acid and preparation method thereof
  • One-step synthesis of star-shaped gold nanoparticles based on polyglutamic acid and preparation method thereof
  • One-step synthesis of star-shaped gold nanoparticles based on polyglutamic acid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) 4 mg of γ-PGA was dissolved in 4 mL of 0.05M sodium bicarbonate solution, placed in a 5 mL centrifuge tube, and sonicated for 5 min.

[0029] (2) Take 1 mL of the above solution into a 10 mL reaction flask.

[0030] (3) 3.66 mL of 0.01 M PBS buffer solution with pH of 7.3 was added, and stirred for 5 min.

[0031] (4) Quickly add 106 μL of 24.13 mM HAuCl 4 , the above solution was stirred for 4h in the dark.

[0032] (5) Quickly add 287 μL of 445 mM NH 2 OH·HCl, and stirred for 40 min in the dark.

[0033] (6) 14000rpm, 8min centrifugation three times to obtain GNS.

[0034] The particle size of the obtained GNS based on one-step synthesis of γ-PGA is about 1 μm.

Embodiment 2

[0036] (1) 2 mg of γ-PGA was dissolved in 4 mL of 0.05M sodium bicarbonate solution, placed in a 5 mL centrifuge tube, and sonicated for 5 min.

[0037] (2)-(3) are the same as steps (2)-(3) in Example 1.

[0038] (4) Quickly add 106 μL of 12.07 mM HAuCl 4 , the above solution was stirred for 4h in the dark.

[0039] (5)-(6) are the same as steps (5)-(6) in Example 1.

[0040] The particle size of the obtained GNS based on one-step synthesis of γ-PGA is about 380 nm.

Embodiment 3

[0042] (1) 4 mg of γ-PGA was dissolved in 4 mL of 0.05M sodium bicarbonate solution, placed in a 5 mL centrifuge tube, and sonicated for 5 min.

[0043] (2)-(3) are the same as steps (2)-(3) in Example 1.

[0044] (4) Quickly add 106 μL of 12.07 mM HAuCl 4 , the above solution was stirred for 4h in the dark.

[0045] (5)-(6) are the same as steps (5)-(6) in Example 1.

[0046] The particle size of the obtained GNS based on one-step synthesis of γ-PGA is about 509 nm.

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Abstract

The invention discloses a star-shaped gold nano particle based on one-step synthesis of polyglutamic acid and a preparation method thereof. GNS is based on hydroxylamine hydrochloride (NH 2 OH·HCl) as reducing agent, in situ reduction of chloroauric acid (HAuCl 4 ) synthesized in one step. The present invention adjusts the concentration of γ-PGA, HAuCl 4 Concentration, NH 2 The concentration, pH, and reduction time of OH·HCl can effectively control the size and morphology of GNSs, and it was found that ε‑polylysine (ε‑PL) could not obtain star-shaped nanoparticles under the same conditions. The as-prepared GNSs range in size from 230 nm to 1 μm. The method has the advantages of simple operation, short time consumption, less consumables, no need for organic solvents, mild and controllable synthesis conditions, and strong reproducibility.

Description

technical field [0001] The invention belongs to the field of nanomaterials and their preparation, in particular to a star-shaped gold nanoparticle (GNS) synthesized by one-step γ-PGA and a preparation method thereof. Background technique [0002] Gold nanomaterials (eg: gold nanospheres, gold nanorods, gold nanocages, gold nanostars) have broad application prospects in the field of biomedicine due to their unique physical and chemical properties. Among them, gold nanostars (GNSs) have shown excellent The photothermal effect has received extensive attention from scientists. At present, the gold seed-mediated method is basically used to prepare GNS. Barbosa et al. used dimethylformamide as the organic solvent, 2-30 nm gold seeds, and the seed-mediated method to synthesize branched gold nanoparticles (Langmuir 2010, 26, 14943). –14950). Schuetz et al. reported a method for seed-mediated synthesis of gold nanostars using hydroquinone as reducing agent and capping agent, 10 nm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B22F1/054B82Y30/00B82Y40/00
CPCB22F9/24B82Y30/00B82Y40/00B22F1/0553B22F1/07B22F1/054
Inventor 申鹤云赵美君白林涛马俊杰
Owner BEIJING UNIV OF CHEM TECH
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