133results about How to "No need for high temperature and high pressure" patented technology

The present invention provides a flaky structure layered composite hydroxide and a preparation method thereof. According to the preparation method, a metal hydroxide, an oxide, a basic carbonate, a metal soluble salt and an alkali are adopted as raw materials, the addition speed of the alkali solution is controlled to prepare the flaky LDH, and the space confinement effect of the metal hydroxide, the oxide or the basic carbonate exists, such that the produced LDH flakes do not easily aggregate so as to finally obtain the LDH with a large specific surface, wherein the BET specific surface area is 130-200 m<2>/g and is much larger than the specific surface area of the ordinary LDH. According to the invention, the preparation method has characteristics of simpleness, no requirement of high temperature, high pressure and special equipment, rich raw material source and low cost; and the flaky structure layered composite hydroxide can be widely used in the fields of absorption separation, catalysis, polymer materials and the like.

The invention discloses a gold nanocluster-gold nanoparticle-titanium dioxide compound photocatalyst and application thereof. The gold nanocluster-gold nanoparticle-titanium dioxide compound photocatalyst having different particle sizes is firstly obtained by preparing a gold nanocluster solution based on chloroauric acid and a reducing type glutathione as raw materials and carrying out an impregnation method and illumination condition control on gold nanocluster solution and titanium dioxide nanoparticles. The gold nanocluster-gold nanoparticle-titanium dioxide compound photocatalyst is simple in preparation method without high temperature and high pressure conditions; compared with the existing gold nanocluster-titanium dioxide and gold nanoparticle-titanium dioxide catalysts, the gold nanocluster-gold nanoparticle-titanium dioxide compound photocatalyst disclosed by the invention is higher in photocatalytic efficiency and hydrogen production efficiency, can be used for hydrogen production by photolysis of water, and is beneficial to sustainable development of environments and energy sources.

The invention provides a three-dimensional flower-like layered double hydroxide and a preparation method thereof. In the preparation of the three-dimensional flower-like layered double hydroxide, aluminum sulfate or aluminum ammonium sulfate, soluble divalent metal salt and alkali are used as raw materials; the characteristic that sphere-like micron-sized aluminium hydroxide particles can be rapidly formed by solution of aluminum sulfate and aluminum ammonium sulfate, of which the pH value is 3.7 to 4, under a temperature of 95 to 100 DEG C is utilized; after being prepared, the micron-sized particles react with the divalent metal salt and the alkali, so that a great amount of LDH (Layered Double Hydroxide) crystal nuclei can be rapidly formed on the surface of aluminium hydroxide; and finally, three-dimensional flower-like structure LDH are formed. A prepared LDH laminate has a thickness of about 10 to 20nm; and the BET (Brunauer-Emmett-Teller) specific surface area of the prepared LDH laminate is greater than 140 m<2>/g and is much greater than that of common LDH. The preparation method disclosed by the invention is simple, is simple and convenient to operate, does not require high temperature and high pressure, does not need to use an organic solvent and a surfactant and is low in cost. The three-dimensional flower-like layered double hydroxide can be widely applied to the fields of adsorption separation, catalysis, high polymer materials and the like.

The invention discloses a synthesis process of vecuronium bromide. The synthesis process comprises the following steps: generating epiandrosterone sulfonyl ester (III) by carrying out esterification reaction between epiandrosterone (II) and paratoluensulfonylchloride; generating 5Alpha-androst-2-alkene-17-ketone (IV) by carrying out elimination and dehydration reaction between the (III) and 2,6-lutidines; generating 17-acetoxyl-5Alpha-androstane-2,16-diene (V) by carrying out enolization and esterification reaction between the (IV) and isopropenyl acetate; generating (2Alpha, 3Alpha, 16Alpha,17Alpha)-diepoxy-17Beta-acetyl-5Alpha-androstane (VI) by epoxy reaction of the (V) under the effect of hydrogen peroxide; generating 2Beta, 16Beta-di(1-piperidyl)-5Alpha-androstane-3Alpha-hydroxyl-17-ketone (VII) by ring-opening and addition reaction of the (VI) under the effect of hexahydropyridine; generating 2Beta, 16Beta-di(1-piperidyl)-5Alpha-androstane-3Alpha,17Beta-diol (VIII) by the (VII)under the reduction of potassium borohydride; generating 2Beta, 16Beta-di(1-piperidyl)-3Alpha, 17Beta- acetoxyl-5Alpha-androstane (IX) by carrying out esterification reaction of the (VIII) under the acetylation of acetic anhydride; and generating vecuronium bromide (I) by carrying out quaternary ammonium salt reaction between the (IX) and bromomethane. The invention has the advantages of low cost,less pollution and high yield.

The invention relates to a long-carbon-chain semi-aromatic nylon PA14T and a preparation method thereof, belonging to the field of high polymer material synthetic technologies. The repeat unit is shown in the specification, and the degree of polymerization of the long-carbon-chain semi-aromatic nylon PA14T is n which is equal to 2 to 200. The preparation method comprises the following steps: (1) preparing nylon PA14T salt: adding 1,4-terephthalic acid and 1,14-tetradecanedioic diamine into water to perform salt forming reaction; (2) preparing semi-aromatic nylon PA14T: adding the nylon PA14T salt obtained in step (1) and a solvent into a polymerizer, heating up a reaction still to be at 200-240 DEG C under a condition of shielding gas, reacting for 1-4 hours under the pressure of 1.2 to 3 MPa, deflating until normal pressure is achieved and vacuumizing, and then carrying out polymerization reaction to obtain the semi-aromatic nylon PA14T. The PA14T is excellent in performance and is easy to process and form, and has the good market prospect, especially in electronic and electrical, automotive industries and the like; and besides, the long-carbon-chain semi-aromatic nylon PA14T is simple in technology, moderate in reaction condition, short in reaction time and low in energy consumption.

The invention discloses a method for preparing a 2-cyano-3-amino acrylic ester derivative, which comprises the following steps: a compound (I) is taken as a raw material and reacts with C1 to C6 of fatty alcohols in an organic solvent in the presence of dry chlorine hydride to generate hydrochloride (II) of iminoether; and the obtained hydrochloride (II) of the iminoether or the filtered hydrochloride (II) of the iminoether reacts with cyanoacetate in the organic solvent in the presence of alkali to obtain the 2-cyano-3-amino acrylic ester derivative (III). The method for preparing the 2-cyano-3-amino acrylic ester derivative simplifies production process and has less three wastes; and the obtained product has high purity and high yield.

The invention mainly relates to the technical field of silk processing, and discloses an environment-friendly silk degumming method, which includes immersion, enzymolysis, fermentation and washing. The method is simple, conditions are mild, high temperature and high pressure are not needed, energy is saved, the method is suitable for batch processing, the degumming rate can reach 89.3 percent, obtain silk is fine and smooth, the color is bright and white-yellow, and economic income can be increased by 12.7 percent. pH of immersed silk is regulated to be alkaline, lipase is added to decompose grease and wax components in the silk, high-temperature cooking is avoided, so that energy is saved, pH is then regulated to be acidic, bromelain is added, and enzymic preparations with different pHs are sequentially used for enzymolysis. The conventional joint use of alkaline protease and surfactant is changed, the environment is protected, soluble impurities under different pHs are sufficiently removed, sericin and remaining fat are decomposed, and the silk degumming rate is increased.

The invention discloses folic acid-functionalized drug-loaded mesoporous silica and a preparation method thereof. The folic acid-functionalized drug-loaded mesoporous silica of the present invention is prepared according to the following steps: 1) adopting orthosilicate as a silicon source, adopting an n-hexadecyl quaternary ammonium salt as a template agent, adopting mercaptopropyl trimethoxysilane as a functionalization reagent, and adopting a method of copolycondensation, synthesis and grafting to prepare thiol-functionalized mesoporous silica; 2) carrying out a reaction of the thiol-functionalized mesoporous silica and 2-(pyridindithio)ethyl ammonium chloride to obtain amino-functionalized mesoporous silica adopting a disulfide bond as a linker; 3) adopting a physical adsorption method to assemble a drug into pore channels of the mesoporous silica; and 4) linking folic acid to the mesoporous silica through the disulfide bond with a covalence effect to obtain the folic acid-functionalized drug-loaded mesoporous silica. The product of the present invention has characteristics of folic acid targeting effect, large specific surface area, high thermal stability, no toxicity, high drug loading rate, and effective prevention from drug leakage.

The invention belongs to the technical field of organosilicone and discloses a quaternary ammonium salt modified diamine-terminated polydimethylsiloxane emulsion and a preparation method and an application thereof. The emulsion provided by the invention comprises the following components which are obtained by performing a reaction in water in parts by mass: 100 parts of diamine-terminated polydimethylsiloxane, 0.5-100 parts of quaternary ammonium salt with epoxy groups and 10-300 parts of a nonionic emulsifier. The quaternary ammonium salt modified diamine-terminated polydimethylsiloxane emulsion provided by the invention is prepared in an emulsifying system, so that the problem that the reaction rate is low as materials are not dissolved by one another is solved, and no organic solvents are needed, and the emulsion is high in flexibility and high in practicality; a quaternary ammonium salt functional group is introduced into the molecular framework thereof, so that the product performance of diamine-terminated polydimethylsiloxane is further improved, the stability is good and the anti-yellowing ability is strong. The quaternary ammonium salt modified diamine-terminated polydimethylsiloxane emulsion provided by the invention is simple and feasible in production process, short in production period, free of strict requirements on production equipment, and easily available in raw material, can easily realize industrial production, and provides a conditioning aid which is unique in performance for daily use chemicals and textile industries.

The invention relates to a method for synthesizing a corrosion and scale inhibitor S-carboxyalkylthiosuccinic acid by adopting a one-step method, and belongs to the field of industrial recycling cooling water treatment. The method comprises the following steps of: adding a certain amount of maleic anhydride and distilled water into a flask and preheating the flask in a constant-temperature oil-bathing pan to 70 DEG C till the maleic anhydride is completely dissolved; adding a certain amount of 3-thiohydracrylic acid to the flask so that the 3-thiohydracrylic acid and the maleic anhydride solution are completely mixed and dissolved, and then adding a little amount of D101 alkali resin to the mixed solution; and heating the mixed solution to 125 DEG C, heating and refluxing for 3.5h, carrying out suction filtering while the mixed solution is hot, putting the filtrate into a refrigerator and cooling the filtrate to 4 DEG C to recrystalize, carrying out suction filtering again to obtain filtrate which does not contain volatile substances and can be recycled and reused, collecting filter cakes, putting the filter cakes into a freezer dryer and drying for 48 hours to obtain white powder, namely the corrosion and scale inhibitor. The one-step method synthesis method disclosed by the invention is free of high temperature and high pressure, simple and convenient to operate and capable of effectively avoiding potential safety hazards and environmental pollution in the production process.

The invention relates to a synthesis method of imatinib and imatinib mesylate. The method comprises the following steps: condensing 3-acetylpyridine and N,N-dimethylformamide dimethyl acetal which aretaken as initial raw materials to obtain 3-dimethylamino-1-(3-pyridyl)-2-propen-1-one, then reacting with 2-methyl-5-nitrophenylguanidine nitrate to form a pyrimidine ring, performing nitro reductionto obtain N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine, amidating the N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine and 4-(chloromethyl)benzoyl chloride, performing affinitysubstitution with 1-methylpiperazine to obtain imatinib, and salifying the imatinib and methanesulfonic acid. The products obtained by the method have the advantages of few impurities, simplicity in post-treatment, high total yield, greenness, environmental protection and safety, and is suitable for a production process for large-scale industrial production of imatinib mesylate.

The invention discloses a homogeneous preparation method of a cationic flocculant from bacterial cellulose, which comprises the following steps: bacterial cellulose regeneration, regenerated cellulose dissolution, and etherification-modified homogeneous preparation of the cationic flocculant. The cationic flocculant belongs to a natural high polymer flocculant, is degradable under natural conditions, and lowers the dependence of the traditional high polymers on fossil resources. The turbidity removal rate for kaolin simulated sewage is greater than 75%, and the delivery quantity is at most 0.05%. The cationic flocculant is convenient for storage and transportation, is widely used in the fields of papermaking, urban oilfield sewage treatment and the like, and has important environmental and social benefits.

The invention discloses a method for synthesizing biobased 1,5-pentadiisocyanate. The method comprises the following steps: firstly dissolving triphosgene solid in a solvent to obtain a mixed system for later use; dissolving 1,5-pentamethylene diamine and an acid-binding agent in the solvent to obtain a mixed solution for later use; finally pumping the mixed solution into the mixed system under nitrogen condition, stirring, mixing and reacting; filtering after the reaction is ended, extracting liquid part, carrying out reduced-pressure distillation for removing low-boiling-point compounds, then continuing to carry out reduced-pressure distillation to obtain colorless liquid which is biobased 1,5-pentadiisocyanate.